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Int. J. Mol. Sci. 2001, 2(3), 140-147; doi:10.3390/i2030140
Article

Relaxometric Investigation of Functional Group Placement on MnTPP Derivatives Supports the Role of the Molecular Electrostatic Potential Maps as a Tool to Design New Metalloporphyrins with Larger Relaxivities

Jr. 1,*  and Jr 2
Received: 11 July 2001 / Accepted: 21 August 2001 / Published: 25 August 2001
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Abstract: We report the T1 and T2 NMR (nuclear magnetic resonance) dispersion profiles for a new manganese porphyrin [MnT(2-C)PP] which has an anionic carboxylate group in the ortho position of the phenyl rings on the metalloporphyrin. Previous MEP (molecular electrostatic potential) maps indicated that this judicious derivatization could result in increases in the observed relaxation efficiency. Relaxometric investigations experimentally confirm about a 20 % increase in the relaxation efficiency at clinically relevant field strengths for MnT(2-C)PP compared to the most efficient metalloporphyrin previously reported MnT(4-S)PP. This result supports the hypothesis that electrostatic forces are relevant to the relaxivity of this family of compounds and that the MEP may be used as a tool to design new agents with even larger relaxivities.
Keywords: Metalloporphyrin; relaxometry; contrast agent; MRI; MEP Metalloporphyrin; relaxometry; contrast agent; MRI; MEP
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Bryant, L.H., Jr.; Mercier, G.A., Jr. Relaxometric Investigation of Functional Group Placement on MnTPP Derivatives Supports the Role of the Molecular Electrostatic Potential Maps as a Tool to Design New Metalloporphyrins with Larger Relaxivities. Int. J. Mol. Sci. 2001, 2, 140-147.

AMA Style

Bryant LH, Jr, Mercier GA, Jr. Relaxometric Investigation of Functional Group Placement on MnTPP Derivatives Supports the Role of the Molecular Electrostatic Potential Maps as a Tool to Design New Metalloporphyrins with Larger Relaxivities. International Journal of Molecular Sciences. 2001; 2(3):140-147.

Chicago/Turabian Style

Bryant, L. H., Jr.; Mercier, Gustavo A., Jr. 2001. "Relaxometric Investigation of Functional Group Placement on MnTPP Derivatives Supports the Role of the Molecular Electrostatic Potential Maps as a Tool to Design New Metalloporphyrins with Larger Relaxivities." Int. J. Mol. Sci. 2, no. 3: 140-147.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert