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Preface
Int. J. Mol. Sci. 2001, 2(1), 1-9; doi:10.3390/i2010001
Article

Theoretical Conformational Analysis of Chemotactic Peptides Formyl-Met-Leu-Phe-OMe and Formyl-Met-Acc6-Phe-OMe

1,* , 2, 3 and 3
1 Laboratoire de Recherche, Ecole Supérieur de Technologie, BP 8012 Oasis, Route d'El Jadida, Km 7, Casablanca, Marocco 2 Département de Chimie, Faculté des Sciences et Techniques Fes Sais, Université Sidi Mohamed Ben Abdellah B.P. 2202, Fes, Marocco 3 Laboratoire de Chimie Physique, Département de Chimie, Faculté des Sciences BP 5366- Maârif / Casablanca, Marocco
* Author to whom correspondence should be addressed.
Received: 4 October 2000 / Accepted: 15 December 2000 / Published: 2 February 2001
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Abstract

In order to investigate the proper peptide backbone conformation that is biologically active, the chemotactic peptides formyl-Met-Leu-Phe-OMe and formyl-Met-Acc6-Phe-OMe (Acc6 is the a-a disubstituted amino acid l-aminocyclohexane-1-carboxylic acid) were studied by the theoretical method PEPSEA. This study shows that the parent peptide formyl-Met-Leu-Phe-OMe has a flexible structure, and that the other conformationally constrained peptide has a tendency to form the b turn structure. It also gives evidence against the hypothesis proposing the importance of a formyl group in the interaction with the receptor.
Keywords: Chemotactic peptide; conformation; a-a disubstituted amino acid; intramolecular hydrogen bond Chemotactic peptide; conformation; a-a disubstituted amino acid; intramolecular hydrogen bond
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wazady, Y.; Hassani, C.A.; Lakhdar, M.; Ezzamarty, A. Theoretical Conformational Analysis of Chemotactic Peptides Formyl-Met-Leu-Phe-OMe and Formyl-Met-Acc6-Phe-OMe. Int. J. Mol. Sci. 2001, 2, 1-9.

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