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Int. J. Mol. Sci. 2001, 2(1), 1-9; doi:10.3390/i2010001
Article

Theoretical Conformational Analysis of Chemotactic Peptides Formyl-Met-Leu-Phe-OMe and Formyl-Met-Acc6-Phe-OMe

1,* , 2, 3 and 3
Received: 4 October 2000; Accepted: 15 December 2000 / Published: 2 February 2001
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Abstract: In order to investigate the proper peptide backbone conformation that is biologically active, the chemotactic peptides formyl-Met-Leu-Phe-OMe and formyl-Met-Acc6-Phe-OMe (Acc6 is the a-a disubstituted amino acid l-aminocyclohexane-1-carboxylic acid) were studied by the theoretical method PEPSEA. This study shows that the parent peptide formyl-Met-Leu-Phe-OMe has a flexible structure, and that the other conformationally constrained peptide has a tendency to form the b turn structure. It also gives evidence against the hypothesis proposing the importance of a formyl group in the interaction with the receptor.
Keywords: Chemotactic peptide; conformation; a-a disubstituted amino acid; intramolecular hydrogen bond Chemotactic peptide; conformation; a-a disubstituted amino acid; intramolecular hydrogen bond
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wazady, Y.; Hassani, C.A.; Lakhdar, M.; Ezzamarty, A. Theoretical Conformational Analysis of Chemotactic Peptides Formyl-Met-Leu-Phe-OMe and Formyl-Met-Acc6-Phe-OMe. Int. J. Mol. Sci. 2001, 2, 1-9.

AMA Style

Wazady Y, Hassani CA, Lakhdar M, Ezzamarty A. Theoretical Conformational Analysis of Chemotactic Peptides Formyl-Met-Leu-Phe-OMe and Formyl-Met-Acc6-Phe-OMe. International Journal of Molecular Sciences. 2001; 2(1):1-9.

Chicago/Turabian Style

Wazady, Youssef; Hassani, Chakib A.; Lakhdar, Mahjoub; Ezzamarty, Aziz. 2001. "Theoretical Conformational Analysis of Chemotactic Peptides Formyl-Met-Leu-Phe-OMe and Formyl-Met-Acc6-Phe-OMe." Int. J. Mol. Sci. 2, no. 1: 1-9.



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