Int. J. Mol. Sci. 2001, 2(1), 1-9; doi:10.3390/i2010001
Article

Theoretical Conformational Analysis of Chemotactic Peptides Formyl-Met-Leu-Phe-OMe and Formyl-Met-Acc6-Phe-OMe

1 Laboratoire de Recherche, Ecole Supérieur de Technologie, BP 8012 Oasis, Route d'El Jadida, Km 7, Casablanca, Marocco 2 Département de Chimie, Faculté des Sciences et Techniques Fes Sais, Université Sidi Mohamed Ben Abdellah B.P. 2202, Fes, Marocco 3 Laboratoire de Chimie Physique, Département de Chimie, Faculté des Sciences BP 5366- Maârif / Casablanca, Marocco
* Author to whom correspondence should be addressed.
Received: 4 October 2000; Accepted: 15 December 2000 / Published: 2 February 2001
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Abstract: In order to investigate the proper peptide backbone conformation that is biologically active, the chemotactic peptides formyl-Met-Leu-Phe-OMe and formyl-Met-Acc6-Phe-OMe (Acc6 is the a-a disubstituted amino acid l-aminocyclohexane-1-carboxylic acid) were studied by the theoretical method PEPSEA. This study shows that the parent peptide formyl-Met-Leu-Phe-OMe has a flexible structure, and that the other conformationally constrained peptide has a tendency to form the b turn structure. It also gives evidence against the hypothesis proposing the importance of a formyl group in the interaction with the receptor.
Keywords: Chemotactic peptide; conformation; a-a disubstituted amino acid; intramolecular hydrogen bond

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MDPI and ACS Style

Wazady, Y.; Hassani, C.A.; Lakhdar, M.; Ezzamarty, A. Theoretical Conformational Analysis of Chemotactic Peptides Formyl-Met-Leu-Phe-OMe and Formyl-Met-Acc6-Phe-OMe. Int. J. Mol. Sci. 2001, 2, 1-9.

AMA Style

Wazady Y, Hassani CA, Lakhdar M, Ezzamarty A. Theoretical Conformational Analysis of Chemotactic Peptides Formyl-Met-Leu-Phe-OMe and Formyl-Met-Acc6-Phe-OMe. International Journal of Molecular Sciences. 2001; 2(1):1-9.

Chicago/Turabian Style

Wazady, Youssef; Hassani, Chakib A.; Lakhdar, Mahjoub; Ezzamarty, Aziz. 2001. "Theoretical Conformational Analysis of Chemotactic Peptides Formyl-Met-Leu-Phe-OMe and Formyl-Met-Acc6-Phe-OMe." Int. J. Mol. Sci. 2, no. 1: 1-9.

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