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Int. J. Mol. Sci. 2018, 19(9), 2731; https://doi.org/10.3390/ijms19092731

Microfluidic and Paper-Based Devices for Disease Detection and Diagnostic Research

Cain Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA 70803, USA
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Received: 2 August 2018 / Revised: 5 September 2018 / Accepted: 6 September 2018 / Published: 12 September 2018
(This article belongs to the Special Issue Nanomedicine/Molecular Medicine)
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Abstract

Recent developments in microfluidic devices, nanoparticle chemistry, fluorescent microscopy, and biochemical techniques such as genetic identification and antibody capture have provided easier and more sensitive platforms for detecting and diagnosing diseases as well as providing new fundamental insight into disease progression. These advancements have led to the development of new technology and assays capable of easy and early detection of pathogenicity as well as the enhancement of the drug discovery and development pipeline. While some studies have focused on treatment, many of these technologies have found initial success in laboratories as a precursor for clinical applications. This review highlights the current and future progress of microfluidic techniques geared toward the timely and inexpensive diagnosis of disease including technologies aimed at high-throughput single cell analysis for drug development. It also summarizes novel microfluidic approaches to characterize fundamental cellular behavior and heterogeneity. View Full-Text
Keywords: microfluidic devices; µPADs; lateral flow strip assays; LFSAs; single cell analysis; high-throughput screening; point of care; polydimethylsiloxane; PDMS microfluidic devices; µPADs; lateral flow strip assays; LFSAs; single cell analysis; high-throughput screening; point of care; polydimethylsiloxane; PDMS
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Campbell, J.M.; Balhoff, J.B.; Landwehr, G.M.; Rahman, S.M.; Vaithiyanathan, M.; Melvin, A.T. Microfluidic and Paper-Based Devices for Disease Detection and Diagnostic Research. Int. J. Mol. Sci. 2018, 19, 2731.

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