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Int. J. Mol. Sci. 2018, 19(9), 2701; https://doi.org/10.3390/ijms19092701

Can Plasma Rich in Growth Factors Be Safe for Parental Use? A Safety Study in the Canine Model

1
Bioregenerative Medicine and Applied Surgery Research Group, Department of Animal Medicine and Surgery, Faculty of Veterinary, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain
2
García Cugat Foundation CEU-UCH Chair of Medicine and Regenerative Surgery, 08006 Barcelona, Spain
3
Department of Animal Pathology, Instituto Universitario de Investigaciones Biomédicas y Universitarias, Universidad de Las Palmas de Gran Canaria, 35416 Trasmontaña S/N. Arucas, Spain
*
Author to whom correspondence should be addressed.
Received: 2 August 2018 / Revised: 9 September 2018 / Accepted: 10 September 2018 / Published: 11 September 2018
(This article belongs to the Special Issue Head Tissues Regeneration)
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Abstract

Low invasiveness is the main goal of modern surgery. The use of platelet-rich plasma (PRP) is known to be effective in a variety of applications, such as oral, maxillofacial, orthopedic, dermatologic and cosmetic surgeries. However, a potential ergogenic and carcinogenic effect of PRP derivatives by means of the insulin-like growth factor-1 (IGF-1) pathway has been suggested. Because of this notion, the purpose of this study is to assess the effect of a commercially available PRP-derivative intramuscular injection in the lumbar muscular tissue (local effect) and to determine the IGF-1 blood concentration (systemic effect) on healthy beagle dogs. Local effect was evaluated by computed tomography (CT) scan and echography, and systemic effect was calculated by blood testing on days 0, 14, 28, 42 and 56. No statistically significant changes were observed; thus, PRGF could be considered safe when using therapeutic doses. View Full-Text
Keywords: platelet-rich plasma (PRP); plasma rich in growth factors (PRGF); insulin-like growth factor-1 (IGF-1); canine platelet-rich plasma (PRP); plasma rich in growth factors (PRGF); insulin-like growth factor-1 (IGF-1); canine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Damiá, E.; Chicharro, D.; Rubio, M.; Carrillo, J.M.; Sopena, J.; Cuervo, B.; López, S.; Vilar, J.M. Can Plasma Rich in Growth Factors Be Safe for Parental Use? A Safety Study in the Canine Model. Int. J. Mol. Sci. 2018, 19, 2701.

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