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Int. J. Mol. Sci. 2018, 19(9), 2663; https://doi.org/10.3390/ijms19092663

Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications

Department of Hematology, University Hospital Virgen del Rocio, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Universidad de Sevilla, 41013 Sevilla, Spain
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Received: 6 August 2018 / Revised: 31 August 2018 / Accepted: 4 September 2018 / Published: 8 September 2018
(This article belongs to the Special Issue Vitamin D and Human Health)
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Abstract

Vitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR). It plays a main role in the calcium homeostasis and metabolism. In addition, vitamin D display other important effects called “non-classical actions.” Among them, vitamin D regulates immune cells function and hematopoietic cells differentiation and proliferation. Based on these effects, it is currently being evaluated for the treatment of hematologic malignancies. In addition, vitamin D levels have been correlated with patients’ outcome after allogeneic stem cell transplantation, where it might regulate immune response and, accordingly, might influence the risk of graft-versus-host disease. Here, we present recent advances regarding its clinical applications both in the treatment of hematologic malignancies and in the transplant setting. View Full-Text
Keywords: vitamin D; haematopoiesis; leukaemia; myelodysplastic syndrome; allogeneic stem cell transplantation vitamin D; haematopoiesis; leukaemia; myelodysplastic syndrome; allogeneic stem cell transplantation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Medrano, M.; Carrillo-Cruz, E.; Montero, I.; Perez-Simon, J.A. Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications. Int. J. Mol. Sci. 2018, 19, 2663.

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