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Int. J. Mol. Sci. 2018, 19(8), 2453; https://doi.org/10.3390/ijms19082453

Role of mTOR Signaling in Tumor Microenvironment: An Overview

1
Medical Oncology 1, IRCCS Regina Elena National Cancer Institute, Rome 00144, Italy
2
Department of Molecular Medicine, University of Rome, La Sapienza, Rome 00185, Italy
3
Department Medical Oncology Unit, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona 37100, Italy
4
Medical Oncology, Fondazione Policlinico Universitario “A. Gemelli” IRCCS Università Cattolica del Sacro Cuore, Rome 00168, Italy
*
Author to whom correspondence should be addressed.
Received: 11 July 2018 / Revised: 6 August 2018 / Accepted: 15 August 2018 / Published: 19 August 2018
(This article belongs to the Special Issue mTOR in Human Diseases)
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Abstract

The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME). In recent years, it has been well recognized that cancer cells co-exist and co-evolve with their TME, which is often involved in drug resistance. The mTOR pathway modulates the interactions between the stroma and the tumor, thereby affecting both the tumor immunity and angiogenesis. The activation of mTOR signaling is associated with these pro-oncogenic cellular processes, making mTOR a promising target for new combination therapies. This review highlights the role of mTOR signaling in the characterization and the activity of the TME’s elements and their implications in cancer immunotherapy. View Full-Text
Keywords: mTOR; tumor microenvironment; angiogenesis; immunotherapy mTOR; tumor microenvironment; angiogenesis; immunotherapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Conciatori, F.; Bazzichetto, C.; Falcone, I.; Pilotto, S.; Bria, E.; Cognetti, F.; Milella, M.; Ciuffreda, L. Role of mTOR Signaling in Tumor Microenvironment: An Overview. Int. J. Mol. Sci. 2018, 19, 2453.

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