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Int. J. Mol. Sci. 2018, 19(8), 2293; https://doi.org/10.3390/ijms19082293

The Micro-RNA Expression Profiles of Autoimmune Arthritis Reveal Novel Biomarkers of the Disease and Therapeutic Response

1,2,†
,
1,2,†
and
1,2,3,‡,*
1
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
2
Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA
3
Division of Rheumatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
These authors contributed equally to this work.
Supv. Research Health Scientist, Veterans Affairs.
*
Author to whom correspondence should be addressed.
Received: 16 July 2018 / Revised: 1 August 2018 / Accepted: 3 August 2018 / Published: 5 August 2018
(This article belongs to the Special Issue Research of Pathogenesis and Novel Therapeutics in Arthritis)
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Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease of the joints affecting about 0.3–1% of the population in different countries. About 50–60 percent of RA patients respond to presently used drugs. Moreover, the current biomarkers for RA have inherent limitations. Consequently, there is a need for additional, new biomarkers for monitoring disease activity and responsiveness to therapy of RA patients. We examined the micro-RNA (miRNA) profile of immune (lymphoid) cells of arthritic Lewis rats and arthritic rats treated with celastrol, a natural triterpenoid. Experimental and bioinformatics analyses revealed 8 miRNAs (miR-22, miR-27a, miR-96, miR-142, miR-223, miR-296, miR-298, and miR-451) and their target genes in functional pathways important for RA pathogenesis. Interestingly, 6 of them (miR-22, miR-27a, miR-96, miR-142, miR-223, and miR-296) were further modulated by celastrol treatment. Interestingly, serum levels of miR-142, miR-155, and miR-223 were higher in arthritic versus control rats, whereas miR-212 showed increased expression in celastrol-treated rats compared with arthritic rats or control rats. This is the first study on comprehensive miRNA expression profiling in the adjuvant-induced arthritis (AA) model and it also has revealed new miRNA targets for celastrol in arthritis. We suggest that subsets of the above miRNAs may serve as novel biomarkers of disease activity and therapeutic response in arthritis. View Full-Text
Keywords: adjuvant arthritis; arthritis; biomarkers; celastrol; inflammation; microRNA; miRNA; rat; rheumatoid arthritis; Traditional Chinese medicine; tripterine; triterpenoid adjuvant arthritis; arthritis; biomarkers; celastrol; inflammation; microRNA; miRNA; rat; rheumatoid arthritis; Traditional Chinese medicine; tripterine; triterpenoid
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Dudics, S.; Venkatesha, S.H.; Moudgil, K.D. The Micro-RNA Expression Profiles of Autoimmune Arthritis Reveal Novel Biomarkers of the Disease and Therapeutic Response. Int. J. Mol. Sci. 2018, 19, 2293.

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