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Int. J. Mol. Sci. 2018, 19(4), 1174; https://doi.org/10.3390/ijms19041174

DNA Methylation and Histone Modification in Hypertension

1
Division of Pharmacology and Physiology, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
2
Center for Genomics, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
*
Author to whom correspondence should be addressed.
Received: 10 February 2018 / Revised: 23 March 2018 / Accepted: 9 April 2018 / Published: 12 April 2018
(This article belongs to the Special Issue Role of Genomics in the Management of Hypertension)
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Abstract

Systemic hypertension, which eventually results in heart failure, renal failure or stroke, is a common chronic human disorder that particularly affects elders. Although many signaling pathways involved in the development of hypertension have been reported over the past decades, which has led to the implementation of a wide variety of anti-hypertensive therapies, one half of all hypertensive patients still do not have their blood pressure controlled. The frontier in understanding the molecular mechanisms underlying hypertension has now advanced to the level of epigenomics. Particularly, increasing evidence is emerging that DNA methylation and histone modifications play an important role in gene regulation and are involved in alteration of the phenotype and function of vascular cells in response to environmental stresses. This review seeks to highlight the recent advances in our knowledge of the epigenetic regulations and mechanisms of hypertension, focusing on the role of DNA methylation and histone modification in the vascular wall. A better understanding of the epigenomic regulation in the hypertensive vessel may lead to the identification of novel target molecules that, in turn, may lead to novel drug discoveries for the treatment of hypertension. View Full-Text
Keywords: DNA methylation; histone modifications; vascular smooth muscle cells; endothelial cells; hypertension DNA methylation; histone modifications; vascular smooth muscle cells; endothelial cells; hypertension
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Stoll, S.; Wang, C.; Qiu, H. DNA Methylation and Histone Modification in Hypertension. Int. J. Mol. Sci. 2018, 19, 1174.

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