Nanoparticle Exposure and Hormetic Dose–Responses: An Update
AbstractThe concept of hormesis, as an adaptive response of biological systems to moderate environmental challenges, has raised considerable nano-toxicological interests in view of the rapid pace of production and application of even more innovative nanomaterials and the expected increasing likelihood of environmental and human exposure to low-dose concentrations. Therefore, the aim of this review is to provide an update of the current knowledge concerning the biphasic dose–responses induced by nanoparticle exposure. The evidence presented confirmed and extended our previous findings, showing that hormesis is a generalized adaptive response which may be further generalized to nanoscale xenobiotic challenges. Nanoparticle physico-chemical properties emerged as possible features affecting biphasic relationships, although the molecular mechanisms underlining such influences remain to be fully understood, especially in experimental settings resembling long-term and low-dose realistic environmental exposure scenarios. Further investigation is necessary to achieve helpful information for a suitable assessment of nanomaterial risks at the low-dose range for both the ecosystem function and the human health. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Iavicoli, I.; Leso, V.; Fontana, L.; Calabrese, E.J. Nanoparticle Exposure and Hormetic Dose–Responses: An Update. Int. J. Mol. Sci. 2018, 19, 805.
Iavicoli I, Leso V, Fontana L, Calabrese EJ. Nanoparticle Exposure and Hormetic Dose–Responses: An Update. International Journal of Molecular Sciences. 2018; 19(3):805.Chicago/Turabian Style
Iavicoli, Ivo; Leso, Veruscka; Fontana, Luca; Calabrese, Edward J. 2018. "Nanoparticle Exposure and Hormetic Dose–Responses: An Update." Int. J. Mol. Sci. 19, no. 3: 805.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.