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Int. J. Mol. Sci. 2018, 19(3), 802; https://doi.org/10.3390/ijms19030802

Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels

1
Department of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, Sapienza University of Rome, 00161 Rome, Italy
2
Department of Biomedical Sciences and Clinical Oncology Oncogenomic Research Center, ‘Aldo Moro’ University of Bari, 70124 Bari, Italy
3
Department of Cardiac Rehabilitation, IRCCS San Raffaele, 00163 Rome, Italy
*
Author to whom correspondence should be addressed.
Received: 6 February 2018 / Revised: 6 March 2018 / Accepted: 7 March 2018 / Published: 10 March 2018
(This article belongs to the Special Issue Ion Transporters and Channels in Physiology and Pathophysiology)
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Abstract

Diabetes mellitus is one the strongest risk factors for cardiovascular disease and, in particular, for ischemic heart disease (IHD). The pathophysiology of myocardial ischemia in diabetic patients is complex and not fully understood: some diabetic patients have mainly coronary stenosis obstructing blood flow to the myocardium; others present with coronary microvascular disease with an absence of plaques in the epicardial vessels. Ion channels acting in the cross-talk between the myocardial energy state and coronary blood flow may play a role in the pathophysiology of IHD in diabetic patients. In particular, some genetic variants for ATP-dependent potassium channels seem to be involved in the determinism of IHD. View Full-Text
Keywords: ion channels; coronary blood flow; diabetes mellitus; ischemic heart disease ion channels; coronary blood flow; diabetes mellitus; ischemic heart disease
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Severino, P.; D’Amato, A.; Netti, L.; Pucci, M.; De Marchis, M.; Palmirotta, R.; Volterrani, M.; Mancone, M.; Fedele, F. Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels. Int. J. Mol. Sci. 2018, 19, 802.

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