Next Article in Journal
Urinary Polyamine Biomarker Panels with Machine-Learning Differentiated Colorectal Cancers, Benign Disease, and Healthy Controls
Next Article in Special Issue
Combined Subchronic Toxicity of Aluminum (III), Titanium (IV) and Silicon (IV) Oxide Nanoparticles and Its Alleviation with a Complex of Bioprotectors
Previous Article in Journal
Antisense Oligonucleotide-Based Splicing Correction in Individuals with Leber Congenital Amaurosis due to Compound Heterozygosity for the c.2991+1655A>G Mutation in CEP290
Previous Article in Special Issue
“Nano-Ginseng” for Enhanced Cytotoxicity AGAINST Cancer Cells
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2018, 19(3), 754; https://doi.org/10.3390/ijms19030754

Gold Nanoparticle-Induced Cell Death and Potential Applications in Nanomedicine

1
School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
2
School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China
3
School of Environmental Science and Engineering, Shandong University, Jinan 250100, China
*
Author to whom correspondence should be addressed.
Received: 30 January 2018 / Revised: 1 March 2018 / Accepted: 5 March 2018 / Published: 7 March 2018
(This article belongs to the Collection Bioactive Nanoparticles)
Full-Text   |   PDF [1195 KB, uploaded 7 March 2018]   |  

Abstract

Cell death is crucial to human health and is related to various serious diseases. Therefore, generation of new cell death regulators is urgently needed for disease treatment. Nanoparticles (NPs) are now routinely used in a variety of fields, including consumer products and medicine. Exhibiting stability and ease of decoration, gold nanoparticles (GNPs) could be used in diagnosis and disease treatment. Upon entering the human body, GNPs contact human cells in the blood, targeting organs and the immune system. This property results in the disturbance of cell function and even cell death. Therefore, GNPs may act as powerful cell death regulators. However, at present, we are far from establishing a structure–activity relationship between the physicochemical properties of GNPs and cell death, and predicting GNP-induced cell death. In this review, GNPs’ size, shape, and surface properties are observed to play key roles in regulating various cell death modalities and related signaling pathways. These results could guide the design of GNPs for nanomedicine. View Full-Text
Keywords: gold nanoparticles; cell death; proliferation; apoptosis; necrosis; autophagy gold nanoparticles; cell death; proliferation; apoptosis; necrosis; autophagy
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Sun, H.; Jia, J.; Jiang, C.; Zhai, S. Gold Nanoparticle-Induced Cell Death and Potential Applications in Nanomedicine. Int. J. Mol. Sci. 2018, 19, 754.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top