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Int. J. Mol. Sci. 2018, 19(3), 700; doi:10.3390/ijms19030700

Anti-Hypertensive Effects of Acacia Polyphenol in Spontaneously Hypertensive Rats

Department of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan
These authors contributed equally to this paper.
Author to whom correspondence should be addressed.
Received: 26 December 2017 / Revised: 22 February 2018 / Accepted: 26 February 2018 / Published: 1 March 2018
(This article belongs to the Special Issue Bioactive Phenolics and Polyphenols 2018)
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We have previously demonstrated that acacia polyphenol (AP) exerts strong anti-obesity, anti-diabetic, and anti-atopic dermatitis effects. In the present study, we investigated the anti-hypertensive effects of AP. Spontaneously hypertensive rats (SHR) with hypertension and control Wistar Kyoto rats (WKY) were used. WKY and SHR were fed AP-containing food or AP-free food (control group) ad libitum for 4 weeks, and their blood pressures were measured. After AP administration, both systolic and diastolic blood pressures were significantly lower in the SHR group than in the control group. There were no differences in the systolic or diastolic blood pressure of WKY between the AP group and the control group. Angiotensin-converting enzyme (ACE) activity, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expression, and superoxide dismutase (SOD) activity in SHR kidneys were not altered by AP administration. Blood SOD activity in SHR was significantly higher in the AP group than in the control group. AP exerts anti-hypertensive effects on hypertension but has almost no effect on normal blood pressure. The anti-hypertensive effects of AP may be related to the anti-oxidative effects of increased blood SOD activity. View Full-Text
Keywords: acacia polyphenol; hypertension; superoxide dismutase; nicotinamide adenine dinucleotide phosphate oxidase acacia polyphenol; hypertension; superoxide dismutase; nicotinamide adenine dinucleotide phosphate oxidase

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ikarashi, N.; Toda, T.; Hatakeyama, Y.; Kusunoki, Y.; Kon, R.; Mizukami, N.; Kaneko, M.; Ogawa, S.; Sugiyama, K. Anti-Hypertensive Effects of Acacia Polyphenol in Spontaneously Hypertensive Rats. Int. J. Mol. Sci. 2018, 19, 700.

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