Importance of ERK1/2 in Regulation of Protein Translation during Oocyte Meiosis
AbstractAlthough the involvement of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathway in the regulation of cytostatic factor (CSF) activity; as well as in microtubules organization during meiotic maturation of oocytes; has already been described in detail; rather less attention has been paid to the role of ERK1/2 in the regulation of mRNA translation. However; important data on the role of ERK1/2 in translation during oocyte meiosis have been documented. This review focuses on recent findings regarding the regulation of translation and the role of ERK1/2 in this process in the meiotic cycle of mammalian oocytes. The specific role of ERK1/2 in the regulation of mammalian target of rapamycin (mTOR); eukaryotic translation initiation factor 4E (eIF4E) and cytoplasmic polyadenylation element binding protein 1 (CPEB1) activity is addressed along with additional focus on the other key players involved in protein translation. View Full-Text
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Kalous, J.; Tetkova, A.; Kubelka, M.; Susor, A. Importance of ERK1/2 in Regulation of Protein Translation during Oocyte Meiosis. Int. J. Mol. Sci. 2018, 19, 698.
Kalous J, Tetkova A, Kubelka M, Susor A. Importance of ERK1/2 in Regulation of Protein Translation during Oocyte Meiosis. International Journal of Molecular Sciences. 2018; 19(3):698.Chicago/Turabian Style
Kalous, Jaroslav; Tetkova, Anna; Kubelka, Michal; Susor, Andrej. 2018. "Importance of ERK1/2 in Regulation of Protein Translation during Oocyte Meiosis." Int. J. Mol. Sci. 19, no. 3: 698.
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