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Int. J. Mol. Sci. 2018, 19(2), 481; https://doi.org/10.3390/ijms19020481

The Impact of Aging on Cardio and Cerebrovascular Diseases

1
Departement of Medicine and Surgery, University of Salerno, 84081 Salerno, Italy
2
Vascular Physiopathology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy
3
Heart Department, A.O.U. “San Giovanni di Dio e Ruggi d’Aragona”, 84131 Salerno, Italy
4
Department of Cardiovascular Medicine, A.O.U. Federico II, 80131 Naples, Italy
5
Rehabilitation Department, A.O.U. “San Giovanni di Dio e Ruggi d’Aragona”, 84131 Salerno, Italy
6
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, 04100 Latina, Italy
These authors equally contributed to this work.
*
Author to whom correspondence should be addressed.
Received: 16 January 2018 / Revised: 29 January 2018 / Accepted: 1 February 2018 / Published: 6 February 2018
(This article belongs to the Special Issue The Impact of Aging on Cardio and Cerebrovascular Diseases)
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Abstract

A growing number of evidences report that aging represents the major risk factor for the development of cardio and cerebrovascular diseases. Understanding Aging from a genetic, biochemical and physiological point of view could be helpful to design a better medical approach and to elaborate the best therapeutic strategy to adopt, without neglecting all the risk factors associated with advanced age. Of course, the better way should always be understanding risk-to-benefit ratio, maintenance of independence and reduction of symptoms. Although improvements in treatment of cardiovascular diseases in the elderly population have increased the survival rate, several studies are needed to understand the best management option to improve therapeutic outcomes. The aim of this review is to give a 360° panorama on what goes on in the fragile ecosystem of elderly, why it happens and what we can do, right now, with the tools at our disposal to slow down aging, until new discoveries on aging, cardio and cerebrovascular diseases are at hand. View Full-Text
Keywords: aging; cardiovascular diseases; genetics; molecular mechanisms aging; cardiovascular diseases; genetics; molecular mechanisms
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Izzo, C.; Carrizzo, A.; Alfano, A.; Virtuoso, N.; Capunzo, M.; Calabrese, M.; De Simone, E.; Sciarretta, S.; Frati, G.; Oliveti, M.; Damato, A.; Ambrosio, M.; De Caro, F.; Remondelli, P.; Vecchione, C. The Impact of Aging on Cardio and Cerebrovascular Diseases. Int. J. Mol. Sci. 2018, 19, 481.

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