The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease
AbstractA distinct G-protein coupled receptor that senses changes in extracellular Zn2+, ZnR/GPR39, was found in cells from tissues in which Zn2+ plays a physiological role. Most prominently, ZnR/GPR39 activity was described in prostate cancer, skin keratinocytes, and colon epithelial cells, where zinc is essential for cell growth, wound closure, and barrier formation. ZnR/GPR39 activity was also described in neurons that are postsynaptic to vesicular Zn2+ release. Activation of ZnR/GPR39 triggers Gαq-dependent signaling and subsequent cellular pathways associated with cell growth and survival. Furthermore, ZnR/GPR39 was shown to regulate the activity of ion transport mechanisms that are essential for the physiological function of epithelial and neuronal cells. Thus, ZnR/GPR39 provides a unique target for therapeutically modifying the actions of zinc in a specific and selective manner. View Full-Text
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Hershfinkel, M. The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease. Int. J. Mol. Sci. 2018, 19, 439.
Hershfinkel M. The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease. International Journal of Molecular Sciences. 2018; 19(2):439.Chicago/Turabian Style
Hershfinkel, Michal. 2018. "The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease." Int. J. Mol. Sci. 19, no. 2: 439.
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