Antiangiogenic Effect of Flavonoids and Chalcones: An Update
AbstractChalcones are precursors of flavonoid biosynthesis in plants. Both flavonoids and chalcones are intensively investigated because of a large spectrum of their biological activities. Among others, anticancer and antiangiogenic effects account for the research interest of these substances. Because of an essential role in cancer growth and metastasis, angiogenesis is considered to be a promising target for cancer treatment. Currently used antiangiogenic agents are either synthetic compounds or monoclonal antibodies. However, there are some limitations of their use including toxicity and high price, making the search for new antiangiogenic compounds very attractive. Nowadays it is well known that several natural compounds may modulate basic steps in angiogenesis. A lot of studies, also from our lab, showed that phytochemicals, including polyphenols, are potent modulators of angiogenesis. This review paper is focused on the antiangiogenic effect of flavonoids and chalcones and discusses possible underlying cellular and molecular mechanisms. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Mirossay, L.; Varinská, L.; Mojžiš, J. Antiangiogenic Effect of Flavonoids and Chalcones: An Update. Int. J. Mol. Sci. 2018, 19, 27.
Mirossay L, Varinská L, Mojžiš J. Antiangiogenic Effect of Flavonoids and Chalcones: An Update. International Journal of Molecular Sciences. 2018; 19(1):27.Chicago/Turabian Style
Mirossay, Ladislav; Varinská, Lenka; Mojžiš, Ján. 2018. "Antiangiogenic Effect of Flavonoids and Chalcones: An Update." Int. J. Mol. Sci. 19, no. 1: 27.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.