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Int. J. Mol. Sci. 2018, 19(1), 195; doi:10.3390/ijms19010195

Surface Functionalization and Targeting Strategies of Liposomes in Solid Tumor Therapy: A Review

1
School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong, China
2
School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW 2006, Australia
*
Authors to whom correspondence should be addressed.
Received: 6 December 2017 / Revised: 3 January 2018 / Accepted: 4 January 2018 / Published: 9 January 2018
(This article belongs to the Collection Bioactive Nanoparticles)
View Full-Text   |   Download PDF [4240 KB, uploaded 9 January 2018]   |  

Abstract

Surface functionalization of liposomes can play a key role in overcoming the current limitations of nanocarriers to treat solid tumors, i.e., biological barriers and physiological factors. The phospholipid vesicles (liposomes) containing anticancer agents produce fewer side effects than non-liposomal anticancer formulations, and can effectively target the solid tumors. This article reviews information about the strategies for targeting of liposomes to solid tumors along with the possible targets in cancer cells, i.e., extracellular and intracellular targets and targets in tumor microenvironment or vasculature. Targeting ligands for functionalization of liposomes with relevant surface engineering techniques have been described. Stimuli strategies for enhanced delivery of anticancer agents at requisite location using stimuli-responsive functionalized liposomes have been discussed. Recent approaches for enhanced delivery of anticancer agents at tumor site with relevant surface functionalization techniques have been reviewed. Finally, current challenges of functionalized liposomes and future perspective of smart functionalized liposomes have been discussed. View Full-Text
Keywords: liposomes; targeted drug delivery; solid tumor; targeting ligands; surface functionalization liposomes; targeted drug delivery; solid tumor; targeting ligands; surface functionalization
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Riaz, M.K.; Riaz, M.A.; Zhang, X.; Lin, C.; Wong, K.H.; Chen, X.; Zhang, G.; Lu, A.; Yang, Z. Surface Functionalization and Targeting Strategies of Liposomes in Solid Tumor Therapy: A Review. Int. J. Mol. Sci. 2018, 19, 195.

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