The Osteogenic Differentiation Effect of the FN Type 10-Peptide Amphiphile on PCL Fiber
AbstractThe fibronectin type 10-peptide amphiphile (FNIII10-PA) was previously genetically engineered and showed osteogenic differentiation activity on rat bone marrow stem cells (rBMSCs). In this study, we investigated whether FNIII10-PA demonstrated cellular activity on polycaprolactone (PCL) fibers. FNIII10-PA significantly increased protein production and cell adhesion activity on PCL fibers in a dose-dependent manner. In cell proliferation results, there was no effect on cell proliferation activity by FNIII10-PA; however, FNIII10-PA induced the osteogenic differentiation of MC3T3-E1 cells via upregulation of bone sialoprotein (BSP), collagen type I (Col I), osteocalcin (OC), osteopontin (OPN), and runt-related transcription factor 2 (Runx2) mitochondrial RNA (mRNA) levels; it did not increase the alkaline phosphatase (ALP) mRNA level. These results indicate that FNIII10-PA has potential as a new biomaterial for bone tissue engineering applications. View Full-Text
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Yun, Y.-R.; Kim, H.-W.; Jang, J.-H. The Osteogenic Differentiation Effect of the FN Type 10-Peptide Amphiphile on PCL Fiber. Int. J. Mol. Sci. 2018, 19, 153.
Yun Y-R, Kim H-W, Jang J-H. The Osteogenic Differentiation Effect of the FN Type 10-Peptide Amphiphile on PCL Fiber. International Journal of Molecular Sciences. 2018; 19(1):153.Chicago/Turabian Style
Yun, Ye-Rang; Kim, Hae-Won; Jang, Jun-Hyeog. 2018. "The Osteogenic Differentiation Effect of the FN Type 10-Peptide Amphiphile on PCL Fiber." Int. J. Mol. Sci. 19, no. 1: 153.
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