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Int. J. Mol. Sci. 2017, 18(9), 1898; doi:10.3390/ijms18091898

Potential Roles of Intrinsic Disorder in Maternal-Effect Proteins Involved in the Maintenance of DNA Methylation

1,2,†
,
1,2,3,†
,
1,2
,
1,2
and
1,2,*
1
College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China
2
Key Laboratory of Animal Biotechnology, Ministry of Agriculture, Northwest A&F University, Yangling 712100, China
3
College of Eco-Environmental Engineering, Qinghai University, Xining 810016, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 22 July 2017 / Revised: 21 August 2017 / Accepted: 22 August 2017 / Published: 4 September 2017
(This article belongs to the Section Molecular Biophysics)
View Full-Text   |   Download PDF [7088 KB, uploaded 4 September 2017]   |  

Abstract

DNA methylation is an important epigenetic modification that needs to be carefully controlled as a prerequisite for normal early embryogenesis. Compelling evidence now suggests that four maternal-effect proteins, primordial germ cell 7 (PGC7), zinc finger protein 57 (ZFP57), tripartite motif-containing 28 (TRIM28) and DNA methyltransferase (cytosine-5) 1 (DNMT1) are involved in the maintenance of DNA methylation. However, it is still not fully understood how these maternal-effect proteins maintain the DNA methylation imprint. We noticed that a feature common to these proteins is the presence of significant levels of intrinsic disorder so in this study we started from an intrinsic disorder perspective to try to understand these maternal-effect proteins. To do this, we firstly analysed the intrinsic disorder predispositions of PGC7, ZFP57, TRIM28 and DNMT1 by using a set of currently available computational tools and secondly conducted an intensive literature search to collect information on their interacting partners and structural characterization. Finally, we discuss the potential effect of intrinsic disorder on the function of these proteins in maintaining DNA methylation. View Full-Text
Keywords: PGC7/DPPA3/STELLA; ZFP57; TRIM28/KAP1/TIF1β; DNMT1; intrinsic disorder; protein–protein interaction PGC7/DPPA3/STELLA; ZFP57; TRIM28/KAP1/TIF1β; DNMT1; intrinsic disorder; protein–protein interaction
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Liu, H.; Wei, Q.; Huang, C.; Zhang, Y.; Guo, Z. Potential Roles of Intrinsic Disorder in Maternal-Effect Proteins Involved in the Maintenance of DNA Methylation. Int. J. Mol. Sci. 2017, 18, 1898.

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