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Int. J. Mol. Sci. 2017, 18(7), 1584; doi:10.3390/ijms18071584

DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol

1
Institute of Molecular Genetics of Russian Academy of Sciences, Kurchatov sq. 2, 123182 Moscow, Russia
2
Department of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 26 June 2017 / Revised: 14 July 2017 / Accepted: 16 July 2017 / Published: 21 July 2017
(This article belongs to the Special Issue Chemically-Induced DNA Damage, Mutagenesis, and Cancer)
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Abstract

PrimPol is a human deoxyribonucleic acid (DNA) polymerase that also possesses primase activity and is involved in DNA damage tolerance, the prevention of genome instability and mitochondrial DNA maintenance. In this review, we focus on recent advances in biochemical and crystallographic studies of PrimPol, as well as in identification of new protein-protein interaction partners. Furthermore, we discuss the possible functions of PrimPol in both the nucleus and the mitochondria. View Full-Text
Keywords: PrimPol; replication; DNA damage; mitochondria PrimPol; replication; DNA damage; mitochondria
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Boldinova, E.O.; Wanrooij, P.H.; Shilkin, E.S.; Wanrooij, S.; Makarova, A.V. DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol. Int. J. Mol. Sci. 2017, 18, 1584.

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