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Int. J. Mol. Sci. 2017, 18(7), 1547; doi:10.3390/ijms18071547

Non-Coding RNAs as Predictive Biomarkers to Current Treatment in Metastatic Colorectal Cancer

1
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Sant’Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy
2
Interdepartmental Centre of Cancer Research “Giorgio Prodi”, University of Bologna, 40138 Bologna, Italy
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 30 April 2017 / Revised: 13 July 2017 / Accepted: 14 July 2017 / Published: 17 July 2017
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Abstract

The onset and selection of resistant clones during cancer treatment with chemotherapy or targeted therapy is a major issue in the clinical management of metastatic colorectal cancer patients. It is possible that a more personalized treatment selection, using reliable response-to-therapy predictive biomarkers, could lead to an improvement in the success rate of the proposed therapies. Although the process of biomarker selection and validation could be a long one, requiring solid statistics, large cohorts and multicentric validations, non-coding RNAs (ncRNAs) and in particular microRNAs, proved to be extremely promising in this field. Here we summarize some of the main studies correlating specific ncRNAs with sensitivity/resistance to chemotherapy, anti-VEGF therapy, anti-EGFR therapy and immunotherapy in colorectal cancer (CRC). View Full-Text
Keywords: colorectal cancer; non-coding RNA; microRNA; predictive biomarker colorectal cancer; non-coding RNA; microRNA; predictive biomarker
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Garajová, I.; Ferracin, M.; Porcellini, E.; Palloni, A.; Abbati, F.; Biasco, G.; Brandi, G. Non-Coding RNAs as Predictive Biomarkers to Current Treatment in Metastatic Colorectal Cancer. Int. J. Mol. Sci. 2017, 18, 1547.

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