Non-Coding RNAs as Predictive Biomarkers to Current Treatment in Metastatic Colorectal Cancer
AbstractThe onset and selection of resistant clones during cancer treatment with chemotherapy or targeted therapy is a major issue in the clinical management of metastatic colorectal cancer patients. It is possible that a more personalized treatment selection, using reliable response-to-therapy predictive biomarkers, could lead to an improvement in the success rate of the proposed therapies. Although the process of biomarker selection and validation could be a long one, requiring solid statistics, large cohorts and multicentric validations, non-coding RNAs (ncRNAs) and in particular microRNAs, proved to be extremely promising in this field. Here we summarize some of the main studies correlating specific ncRNAs with sensitivity/resistance to chemotherapy, anti-VEGF therapy, anti-EGFR therapy and immunotherapy in colorectal cancer (CRC). View Full-Text
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Garajová, I.; Ferracin, M.; Porcellini, E.; Palloni, A.; Abbati, F.; Biasco, G.; Brandi, G. Non-Coding RNAs as Predictive Biomarkers to Current Treatment in Metastatic Colorectal Cancer. Int. J. Mol. Sci. 2017, 18, 1547.
Garajová I, Ferracin M, Porcellini E, Palloni A, Abbati F, Biasco G, Brandi G. Non-Coding RNAs as Predictive Biomarkers to Current Treatment in Metastatic Colorectal Cancer. International Journal of Molecular Sciences. 2017; 18(7):1547.Chicago/Turabian Style
Garajová, Ingrid; Ferracin, Manuela; Porcellini, Elisa; Palloni, Andrea; Abbati, Francesca; Biasco, Guido; Brandi, Giovanni. 2017. "Non-Coding RNAs as Predictive Biomarkers to Current Treatment in Metastatic Colorectal Cancer." Int. J. Mol. Sci. 18, no. 7: 1547.
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