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Int. J. Mol. Sci. 2017, 18(7), 1397; doi:10.3390/ijms18071397

Loss of Bone Mineral Density Associated with Age in Male Rats Fed on Sunflower Oil Is Avoided by Virgin Olive Oil Intake or Coenzyme Q Supplementation

1
Institute of Nutrition and Food Technology “José Mataix Verdú”, Biomedical Research Center, University of Granada, Avda del Conocimiento s.n., Armilla, 18016 Granada, Spain
2
Department of Physiology, Faculty of Pharmacy, University of Granada, Calle del Prof. Clavera s.n., 18071 Granada, Spain
4
Department of Medicine and Science of Aging, University of Chieti “G. D’Annunzio”, 66100 Chieti, Italy
5
Department of Scienze Cliniche Specialistiche ed Odontostomatologiche, Università Politecnica delle Marche, 60131 Ancona, Italy
3
Nuclear Medicine Service, Hospital Virgen de las Nieves, Avda. de las Fuerzas Armadas 2, 18014 Granada, Spain
*
Author to whom correspondence should be addressed.
Received: 3 May 2017 / Revised: 20 June 2017 / Accepted: 22 June 2017 / Published: 29 June 2017
(This article belongs to the Special Issue Correlation between Nutrition, Oxidative Stress and Disease)
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Abstract

The role of dietary fat unsaturation and the supplementation of coenzyme Q have been evaluated in relation to bone health. Male Wistar rats were maintained for 6 or 24 months on two diets varying in the fat source, namely virgin olive oil, rich in monounsaturated fatty acids, or sunflower oil, rich in n-6 polyunsaturated fatty acids. Both dietary fats were supplemented or not with coenzyme Q10 (CoQ10). Bone mineral density (BMD) was evaluated in the femur. Serum levels of osteocalcin, osteopontin, receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), adrenocorticotropin (ACTH) and parathyroid hormone (PTH), as well as urinary F2-isoprostanes were measured. Aged animals fed on virgin olive oil showed higher BMD than those fed on sunflower oil. In addition, CoQ10 prevented the age-related decline in BMD in animals fed on sunflower oil. Urinary F2-isoprostanes analysis showed that sunflower oil led to the highest oxidative status in old animals, which was avoided by supplementation with CoQ10. In conclusion, lifelong feeding on virgin olive oil or the supplementation of sunflower oil on CoQ10 prevented, at least in part mediated by a low oxidative stress status, the age-related decrease in BMD found in sunflower oil fed animals. View Full-Text
Keywords: bone mineral density; F2-isoprostanes; oxidative stress; MUFA; PUFA bone mineral density; F2-isoprostanes; oxidative stress; MUFA; PUFA
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Varela-López, A.; Ochoa, J.J.; Llamas-Elvira, J.M.; López-Frías, M.; Planells, E.; Speranza, L.; Battino, M.; Quiles, J.L. Loss of Bone Mineral Density Associated with Age in Male Rats Fed on Sunflower Oil Is Avoided by Virgin Olive Oil Intake or Coenzyme Q Supplementation. Int. J. Mol. Sci. 2017, 18, 1397.

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