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Int. J. Mol. Sci. 2017, 18(4), 867; doi:10.3390/ijms18040867

Chemopreventive Strategies for Inflammation-Related Carcinogenesis: Current Status and Future Direction

1
Division of Pathological Biochemistry, Tottori University Faculty of Medicine, Yonago, Tottori 683-8503, Japan
2
Chromosome Engineering Research Center, Tottori University, Yonago, Tottori 683-8503, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Takuji Tanaka and Masahito Shimizu
Received: 31 March 2017 / Revised: 14 April 2017 / Accepted: 17 April 2017 / Published: 19 April 2017
(This article belongs to the Special Issue Inflammation and Cancer)
View Full-Text   |   Download PDF [2171 KB, uploaded 20 April 2017]   |  

Abstract

A sustained and chronically-inflamed environment is characterized by the presence of heterogeneous inflammatory cellular components, including neutrophils, macrophages, lymphocytes and fibroblasts. These infiltrated cells produce growth stimulating mediators (inflammatory cytokines and growth factors), chemotactic factors (chemokines) and genotoxic substances (reactive oxygen species and nitrogen oxide) and induce DNA damage and methylation. Therefore, chronic inflammation serves as an intrinsic niche for carcinogenesis and tumor progression. In this article, we summarize the up-to-date findings regarding definitive/possible causes and mechanisms of inflammation-related carcinogenesis derived from experimental and clinical studies. We also propose 10 strategies, as well as candidate agents for the prevention of inflammation-related carcinogenesis. View Full-Text
Keywords: inflammation-related carcinogenesis; chronic inflammation; chemoprevention inflammation-related carcinogenesis; chronic inflammation; chemoprevention
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Kanda, Y.; Osaki, M.; Okada, F. Chemopreventive Strategies for Inflammation-Related Carcinogenesis: Current Status and Future Direction. Int. J. Mol. Sci. 2017, 18, 867.

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