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Int. J. Mol. Sci. 2017, 18(4), 707; doi:10.3390/ijms18040707

The Balloon-Based Manometry Evaluation of Swallowing in Patients with Amyotrophic Lateral Sclerosis

1
Ear, Nose & Throat (ENT) Department, Faculty of Medicine, Jagiellonian University Medical College, Kraków 31-531, Poland
2
Department of Neurology, Faculty of Medicine, Jagiellonian University Medical College, Kraków 31-503, Poland
3
Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, Kraków 31-531, Poland
4
Department of Prosthetic Dentistry, Faculty of Medicine, Jagiellonian University Medical College, Kraków 31-155, Poland
5
Department of Pharmacology, Faculty of Medicine, Jagiellonian University Medical College, Kraków 31-531, Poland
*
Author to whom correspondence should be addressed.
Academic Editors: Charles J. Malemud and Alexander Remels
Received: 25 January 2017 / Revised: 10 March 2017 / Accepted: 22 March 2017 / Published: 27 March 2017
(This article belongs to the Special Issue Musculoskeletal Diseases Therapy)
View Full-Text   |   Download PDF [211 KB, uploaded 27 March 2017]

Abstract

The aim of the study was to analyse the disturbances of the oro-pharyngeal swallowing phase of dysphagia in amyotrophic lateral sclerosis (ALS) patients with the use of specific manometric measurements and to evaluate their plausible association with the duration of the disease. Seventeen patients with ALS were evaluated with manometric examinations of the oral and pharyngeal part of the gastrointestinal tract. Tests were carried out by using the oesophageal balloon-based method with four balloon transducers located 5 cm away from each other. The following manometric parameters were analysed: the base of tongue contraction (BTC) and the upper oesophageal sphincter pressure (UESP), and the hypopharyngeal suction pump (HSP) as well as the oro-pharyngeal, pharyngeal and hypopharyngeal transit time and average pharyngeal bolus velocity (oropharyngeal transit time (OTT), pharyngeal transit time (PTT), hypopharyngeal transit time (HTT) and average pharyngeal bolus velocity (APBV), respectively). Manomatric examinations during swallowing in patients with ALS showed significant weakness of BTC, a decrease of HSP and a decrease of the velocity of bolus transit inside the pharynx which were particularly marked between the first and the third examination. Manometric examinations of the oro-pharyngeal part of the gastrointestinal tract are useful and supportive methods in the analysis of swallowing disturbances in ALS patients. View Full-Text
Keywords: amyotrophic lateral sclerosis; dysphagia; bulbar onset; balloon-based manometry amyotrophic lateral sclerosis; dysphagia; bulbar onset; balloon-based manometry
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Tomik, J.; Tomik, B.; Gajec, S.; Ceranowicz, P.; Pihut, M.; Olszanecki, R.; Stręk, P.; Składzień, J. The Balloon-Based Manometry Evaluation of Swallowing in Patients with Amyotrophic Lateral Sclerosis. Int. J. Mol. Sci. 2017, 18, 707.

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