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Int. J. Mol. Sci. 2017, 18(4), 686; doi:10.3390/ijms18040686

Future Prospects for the Development of Cost-Effective Adenovirus Vaccines

Department of Immunology and Microbiology, Copenhagen University, København K 1014, Denmark
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Author to whom correspondence should be addressed.
Academic Editor: Chang Won Choi
Received: 31 January 2017 / Revised: 17 March 2017 / Accepted: 20 March 2017 / Published: 23 March 2017
(This article belongs to the Special Issue Advances in Cheap Vaccines for Public Goods)
View Full-Text   |   Download PDF [1741 KB, uploaded 27 March 2017]   |  

Abstract

Vaccination is one of the most efficient tools for disease prevention, and a continuously growing field of research. However, despite progress, we still need more efficient and cost-effective vaccines that would improve access to those in need. In this review, we will describe the status of virus-vectored vaccine technology with a focus on adenoviral-based vaccines. Adenovirus (Ad) vaccines have proven to be efficient in military vaccinations against Ad4 and Ad7 and as highly efficient vectored vaccines against rabies. The question of how other adenovirus-based vaccines can become as efficient as the rabies vaccine is the underlying theme in this review. Here, we will first give an overview of the basic properties of vectored vaccines, followed by an introduction to the characteristics of adenoviral vectors and previously tested modifications of the vector backbone and expression cassettes, with a focus on how they can contribute to increased vaccine cost-effectiveness. Finally, we will highlight a few successful examples of research that have attempted to improve the use of adenoviral-based vaccines by improving the transgene immunogenicity. View Full-Text
Keywords: adenovirus; vaccine; replication competent; transgene; affordable vaccine candidates; protective immunity; vaccine technology platform; immune responses adenovirus; vaccine; replication competent; transgene; affordable vaccine candidates; protective immunity; vaccine technology platform; immune responses
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Fougeroux, C.; Holst, P.J. Future Prospects for the Development of Cost-Effective Adenovirus Vaccines. Int. J. Mol. Sci. 2017, 18, 686.

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