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Int. J. Mol. Sci. 2017, 18(3), 645; doi:10.3390/ijms18030645

TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action

1
Department of Respiratory Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China
2
Department of Immunology, School of Medicine, University of Pittsburgh, EBST E1047, 200 Lothrop Street, Pittsburgh, PA 15261, USA
3
Department of Immunology, School of Biology and Basic Medical Science, Soochow University, Suzhou 215123, China
4
Department of Ophthalmology, The Second Hospital of Jilin University, Changchun 130041, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Li Yang
Received: 23 January 2017 / Revised: 3 March 2017 / Accepted: 6 March 2017 / Published: 16 March 2017
(This article belongs to the Special Issue Tumor Microenvironment and Metabolism)
View Full-Text   |   Download PDF [806 KB, uploaded 16 March 2017]   |  

Abstract

Cancer immunotherapy has produced impressive clinical results in recent years. Despite the success of the checkpoint blockade strategies targeting cytotoxic T lymphocyte antigen 4 (CTLA-4) and programmed death receptor 1 (PD-1), a large portion of cancer patients have not yet benefited from this novel therapy. T cell immunoglobulin and mucin domain 3 (TIM-3) has been shown to mediate immune tolerance in mouse models of infectious diseases, alloimmunity, autoimmunity, and tumor Immunity. Thus, targeting TIM-3 emerges as a promising approach for further improvement of current immunotherapy. Despite a large amount of experimental data showing an immune suppressive function of TIM-3 in vivo, the exact mechanisms are not well understood. To enable effective targeting of TIM-3 for tumor immunotherapy, further in-depth mechanistic studies are warranted. These studies will also provide much-needed insight for the rational design of novel combination therapy with other checkpoint blockers. In this review, we summarize key evidence supporting an immune regulatory role of TIM-3 and discuss possible mechanisms of action. View Full-Text
Keywords: TIM-3; T cell subsets; tumor microenvironment; antitumor immune responses TIM-3; T cell subsets; tumor microenvironment; antitumor immune responses
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Du, W.; Yang, M.; Turner, A.; Xu, C.; Ferris, R.L.; Huang, J.; Kane, L.P.; Lu, B. TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action. Int. J. Mol. Sci. 2017, 18, 645.

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