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Int. J. Mol. Sci. 2017, 18(3), 567; doi:10.3390/ijms18030567

Alternative Splicing of hTERT Pre-mRNA: A Potential Strategy for the Regulation of Telomerase Activity

1
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
2
Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin 300070, China
3
Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Hospital, Tianjin 300070, China
4
Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300070, China
5
Department of Clinical Laboratory, General Hospital, Tianjin Medical University, Tianjin 300070, China
6
Department of Genetics, Tianjin Medical University, Tianjin 300070, China
7
Department of Neurology, General Hospital, Tianjin Medical University, Tianjin 300052, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Akila Mayeda
Received: 29 December 2016 / Revised: 14 February 2017 / Accepted: 2 March 2017 / Published: 7 March 2017
(This article belongs to the Special Issue Pre-mRNA Splicing 2016)
View Full-Text   |   Download PDF [574 KB, uploaded 7 March 2017]   |  

Abstract

The activation of telomerase is one of the key events in the malignant transition of cells, and the expression of human telomerase reverse transcriptase (hTERT) is indispensable in the process of activating telomerase. The pre-mRNA alternative splicing of hTERT at the post-transcriptional level is one of the mechanisms for the regulation of telomerase activity. Shifts in splicing patterns occur in the development, tumorigenesis, and response to diverse stimuli in a tissue-specific and cell type–specific manner. Despite the regulation of telomerase activity, the alternative splicing of hTERT pre-mRNA may play a role in other cellular functions. Modulating the mode of hTERT pre-mRNA splicing is providing a new precept of therapy for cancer and aging-related diseases. This review focuses on the patterns of hTERT pre-mRNA alternative splicing and their biological functions, describes the potential association between the alternative splicing of hTERT pre-mRNA and telomerase activity, and discusses the possible significance of the alternative splicing of the hTERT pre-mRNA in the diagnosis, therapy, and prognosis of cancer and aging-related diseases. View Full-Text
Keywords: telomerase; human telomerase reverse transcriptase (hTERT) pre-mRNA; alternative splicing; cancer; aging telomerase; human telomerase reverse transcriptase (hTERT) pre-mRNA; alternative splicing; cancer; aging
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Liu, X.; Wang, Y.; Chang, G.; Wang, F.; Wang, F.; Geng, X. Alternative Splicing of hTERT Pre-mRNA: A Potential Strategy for the Regulation of Telomerase Activity. Int. J. Mol. Sci. 2017, 18, 567.

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