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Open AccessCommunication
Int. J. Mol. Sci. 2017, 18(3), 560; doi:10.3390/ijms18030560

Changes in Brain Monoamines Underlie Behavioural Disruptions after Zebrafish Diet Exposure to Polycyclic Aromatic Hydrocarbons Environmental Mixtures

1
Laboratoire Ressources Halieutiques, Ifremer, Place Gaby Coll, 17137 L’Houmeau, France
2
Unité Écologie et Modèles pour l’Halieutique, Ifremer, B.P. 21105, 44311 Nantes CEDEX 03, France
3
Génomique Fonctionnelle de l'Hypertension Artérielle, EA 4173, University Lyon 1, 8 Avenue Rockefeller, 69373 Lyon CEDEX 08, France
4
Laboratoire Adaptation et Adaptabilités des Animaux et des Systèmes, UMR MARBEC, Ifremer, Route de Maguelone, 34250 Palavas, France
5
GABI, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France
These authors contributed equally to this work.
Present address: Department Environmental Toxicology, Eawag, Überlandstrasse 133, 8600 Dübendorf, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Helmut Segner
Received: 16 January 2017 / Revised: 17 February 2017 / Accepted: 26 February 2017 / Published: 4 March 2017
(This article belongs to the Special Issue Zebrafish: A Model for Toxicological Research)
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Abstract

Zebrafish were exposed through diet to two environmentally relevant polycyclic aromatic hydrocarbons (PAHs) mixtures of contrasted compositions, one of pyrolytic (PY) origin and one from light crude oil (LO). Monoamine concentrations were quantified in the brains of the fish after six month of exposure. A significant decrease in noradrenaline (NA) was observed in fish exposed to both mixtures, while a decrease in serotonin (5HT) and dopamine (DA) was observed only in LO-exposed fish. A decrease in metabolites of 5HT and DA was observed in fish exposed to both mixtures. Several behavioural disruptions were observed that depended on mixtures, and parallels were made with changes in monoamine concentrations. Indeed, we observed an increase in anxiety in fish exposed to both mixtures, which could be related to the decrease in 5HT and/or NA, while disruptions of daily activity rhythms were observed in LO fish, which could be related to the decrease in DA. Taken together, these results showed that (i) chronic exposures to PAHs mixtures disrupted brain monoamine contents, which could underlie behavioural disruptions, and that (ii) the biological responses depended on mixture compositions. View Full-Text
Keywords: monoamine; polycyclic aromatic hydrocarbons; behaviour; anxiety; swimming activity; zebrafish monoamine; polycyclic aromatic hydrocarbons; behaviour; anxiety; swimming activity; zebrafish
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Vignet, C.; Trenkel, V.M.; Vouillarmet, A.; Bricca, G.; Bégout, M.-L.; Cousin, X. Changes in Brain Monoamines Underlie Behavioural Disruptions after Zebrafish Diet Exposure to Polycyclic Aromatic Hydrocarbons Environmental Mixtures. Int. J. Mol. Sci. 2017, 18, 560.

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