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Int. J. Mol. Sci. 2017, 18(2), 398; doi:10.3390/ijms18020398

Increased Serum CD14 Level Is Associated with Depletion of TNF-α in Monocytes in Migraine Patients during Interictal Period

1
Department of Neurochemistry and Neuropathology, Chair of Neurology, Poznan University of Medical Sciences (PUMS), Poznan 60-355, Poland
2
Chair of Neurology, PUMS, Poznan 60-355, Poland
3
Department of Clinical Neuroimmunology, Chair of Neurology, PUMS, Poznan 60-355, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Kurt A. Jellinger
Received: 15 December 2016 / Revised: 26 January 2017 / Accepted: 3 February 2017 / Published: 13 February 2017
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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Abstract

The aim of the present study was to investigate the levels of circulating CD14 in relation to the expression of tumor necrosis factor alpha (TNF-α) in monocytes, and serum levels of TNF-α and macrophage inflammatory protein-1 (MIP-1) in migraine patients. Numerous studies revealed controversial changes in the components of the immune system during attacks and the interictal period in migraine patients. Our study included 40 migraineurs and 39 controls. The levels of TNF-α, MIP-1 and CD14 were measured in peripheral monocytes and in sera with the Enzyme-Linked Immunosorbent Assay (ELISA) method, and the monocyte expression of TNF-α was also analysed by immunostaining. Serum CD14 concentrations were higher and the expression of TNF-α in monocytes was decreased in migraineurs. The serum MIP-1 level correlated with Verbal Rating Scale (VRS); the MIP-1:CD14 ratio in monocytes correlated with Visual Analogue Scale (VAS); the MIP-1:CD14 ratio correlated with Migraine Severity (MIGSEV)-Pain scores; and serum CD14 concentration correlated with migraine duration in years. Increased serum CD14 and depletion of TNF-α in monocytes can orchestrate other components of the immune system during the interictal period. View Full-Text
Keywords: migraine; monocytes; tumor necrosis factor alpha (TNF-α); macrophage inflammatory protein-1 (MIP-1); CD-14 migraine; monocytes; tumor necrosis factor alpha (TNF-α); macrophage inflammatory protein-1 (MIP-1); CD-14
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Michalak, S.; Kalinowska-Lyszczarz, A.; Wegrzyn, D.; Niezgoda, A.; Losy, J.; Osztynowicz, K.; Kozubski, W. Increased Serum CD14 Level Is Associated with Depletion of TNF-α in Monocytes in Migraine Patients during Interictal Period. Int. J. Mol. Sci. 2017, 18, 398.

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