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Int. J. Mol. Sci. 2017, 18(2), 342; doi:10.3390/ijms18020342

Mechanisms of Regulation of the Chemokine-Receptor Network

1
Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia
2
Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Elisabetta Tanzi
Received: 21 December 2016 / Revised: 18 January 2017 / Accepted: 26 January 2017 / Published: 7 February 2017
(This article belongs to the Special Issue Regulation of Chemokine-Receptor Interactions and Functions)
View Full-Text   |   Download PDF [2126 KB, uploaded 7 February 2017]   |  

Abstract

The interactions of chemokines with their G protein-coupled receptors promote the migration of leukocytes during normal immune function and as a key aspect of the inflammatory response to tissue injury or infection. This review summarizes the major cellular and biochemical mechanisms by which the interactions of chemokines with chemokine receptors are regulated, including: selective and competitive binding interactions; genetic polymorphisms; mRNA splice variation; variation of expression, degradation and localization; down-regulation by atypical (decoy) receptors; interactions with cell-surface glycosaminoglycans; post-translational modifications; oligomerization; alternative signaling responses; and binding to natural or pharmacological inhibitors. View Full-Text
Keywords: chemokine; chemokine receptor; regulation; binding; expression; glycosaminoglycan; post-translational modification; oligomerization; signaling; inhibitor chemokine; chemokine receptor; regulation; binding; expression; glycosaminoglycan; post-translational modification; oligomerization; signaling; inhibitor
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Stone, M.J.; Hayward, J.A.; Huang, C.; E. Huma, Z.; Sanchez, J. Mechanisms of Regulation of the Chemokine-Receptor Network. Int. J. Mol. Sci. 2017, 18, 342.

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