Mechanisms of Regulation of the Chemokine-Receptor Network
AbstractThe interactions of chemokines with their G protein-coupled receptors promote the migration of leukocytes during normal immune function and as a key aspect of the inflammatory response to tissue injury or infection. This review summarizes the major cellular and biochemical mechanisms by which the interactions of chemokines with chemokine receptors are regulated, including: selective and competitive binding interactions; genetic polymorphisms; mRNA splice variation; variation of expression, degradation and localization; down-regulation by atypical (decoy) receptors; interactions with cell-surface glycosaminoglycans; post-translational modifications; oligomerization; alternative signaling responses; and binding to natural or pharmacological inhibitors. View Full-Text
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Stone, M.J.; Hayward, J.A.; Huang, C.; E. Huma, Z.; Sanchez, J. Mechanisms of Regulation of the Chemokine-Receptor Network. Int. J. Mol. Sci. 2017, 18, 342.
Stone MJ, Hayward JA, Huang C, E. Huma Z, Sanchez J. Mechanisms of Regulation of the Chemokine-Receptor Network. International Journal of Molecular Sciences. 2017; 18(2):342.Chicago/Turabian Style
Stone, Martin J.; Hayward, Jenni A.; Huang, Cheng; E. Huma, Zil; Sanchez, Julie. 2017. "Mechanisms of Regulation of the Chemokine-Receptor Network." Int. J. Mol. Sci. 18, no. 2: 342.
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