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Int. J. Mol. Sci. 2017, 18(2), 323; doi:10.3390/ijms18020323

A Dual-Modality System for Both Multi-Color Ultrasound-Switchable Fluorescence and Ultrasound Imaging

1
Ultrasound and Optical Imaging Laboratory, Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76010, USA
2
Joint Biomedical Engineering Program, University of Texas at Arlington and University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
3
Department of Chemistry, University of North Texas, 1155, Union Circle, #305070, Denton, TX 76203, USA
4
Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76010, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Sundaresan Gobalakrishnan and Jamal Zweit
Received: 25 October 2016 / Revised: 29 December 2016 / Accepted: 24 January 2017 / Published: 4 February 2017
(This article belongs to the Special Issue Cancer Molecular Imaging in the Era of Precision Medicine)
View Full-Text   |   Download PDF [1687 KB, uploaded 4 February 2017]   |  

Abstract

Simultaneous imaging of multiple targets (SIMT) in opaque biological tissues is an important goal for molecular imaging in the future. Multi-color fluorescence imaging in deep tissues is a promising technology to reach this goal. In this work, we developed a dual-modality imaging system by combining our recently developed ultrasound-switchable fluorescence (USF) imaging technology with the conventional ultrasound (US) B-mode imaging. This dual-modality system can simultaneously image tissue acoustic structure information and multi-color fluorophores in centimeter-deep tissue with comparable spatial resolutions. To conduct USF imaging on the same plane (i.e., x-z plane) as US imaging, we adopted two 90°-crossed ultrasound transducers with an overlapped focal region, while the US transducer (the third one) was positioned at the center of these two USF transducers. Thus, the axial resolution of USF is close to the lateral resolution, which allows a point-by-point USF scanning on the same plane as the US imaging. Both multi-color USF and ultrasound imaging of a tissue phantom were demonstrated. View Full-Text
Keywords: ultrasound-switchable fluorescence imaging; ultrasound imaging; dual-modality imaging; multi-color fluorescence imaging; deep-tissue fluorescence imaging ultrasound-switchable fluorescence imaging; ultrasound imaging; dual-modality imaging; multi-color fluorescence imaging; deep-tissue fluorescence imaging
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kandukuri, J.; Yu, S.; Cheng, B.; Bandi, V.; D’Souza, F.; Nguyen, K.T.; Hong, Y.; Yuan, B. A Dual-Modality System for Both Multi-Color Ultrasound-Switchable Fluorescence and Ultrasound Imaging. Int. J. Mol. Sci. 2017, 18, 323.

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