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Open AccessCommunication
Int. J. Mol. Sci. 2017, 18(2), 303; doi:10.3390/ijms18020303

Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and Topological Effects

1
Institut für Organische Chemie, Universität Regensburg, Universitätsstr. 31, Regensburg 93053, Germany
2
Institut für Pharmazie, Pharmakologie und Toxikologie, Universität Regensburg, Universitätsstr. 31, Regensburg 93053, Germany
3
Institute of Advanced Chemistry of Catalonia-Spanish National Research Council (IQAC-CSIC), Jordi Girona 18-26, Barcelona 08034, Spain
*
Authors to whom correspondence should be addressed.
Academic Editors: Antonella Piozzi and Iolanda Francolini
Received: 6 December 2016 / Revised: 24 January 2017 / Accepted: 26 January 2017 / Published: 30 January 2017
(This article belongs to the Special Issue Antimicrobial Polymers 2016)
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Abstract

A series of polycations bearing quaternary ammonium moieties have shown antimicrobial activity against the Gram-negative bacterium Escherichia coli. Different polymer topologies governed by a disubstituted aromatic core as well as different diamine-based linkers were found to influence the antimicrobial properties. Moreover, the hemolytic activity against human red blood cells was measured and demonstrated good biocompatibility and selectivity of these polycations for bacteria over mammalian cells. View Full-Text
Keywords: antimicrobial polymer; ionenes; polycations; quaternary ammonium; hemolysis; topomers antimicrobial polymer; ionenes; polycations; quaternary ammonium; hemolysis; topomers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mayr, J.; Bachl, J.; Schlossmann, J.; Díaz, D.D. Antimicrobial and Hemolytic Studies of a Series of Polycations Bearing Quaternary Ammonium Moieties: Structural and Topological Effects. Int. J. Mol. Sci. 2017, 18, 303.

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