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Int. J. Mol. Sci. 2017, 18(2), 280; doi:10.3390/ijms18020280

Hormetic Response to Low-Dose Radiation: Focus on the Immune System and Its Clinical Implications

1
Cancer Center, the First Hospital of Jilin University, Changchun 130021, China
2
Department of Radiation-Oncology, the First Hospital of Jilin University, Changchun 130021, China
3
The Pediatric Research Institute, the Departments of Pediatrics, Radiation Oncology, Pharmacology and Toxicology of the University of Louisville, Louisville, KY 40202, USA
*
Authors to whom correspondence should be addressed.
Academic Editors: Guido R.M.M. Haenen, Mireille M.J.P.E. Sthijns and Aalt Bast
Received: 19 December 2016 / Accepted: 17 January 2017 / Published: 27 January 2017
(This article belongs to the Special Issue Hormesis and Transhormesis in Toxicology and Risk Assessment)
View Full-Text   |   Download PDF [410 KB, uploaded 3 February 2017]   |  

Abstract

The interrelationship between ionizing radiation and the immune system is complex, multifactorial, and dependent on radiation dose/quality and immune cell type. High-dose radiation usually results in immune suppression. On the contrary, low-dose radiation (LDR) modulates a variety of immune responses that have exhibited the properties of immune hormesis. Although the underlying molecular mechanism is not fully understood yet, LDR has been used clinically for the treatment of autoimmune diseases and malignant tumors. These advancements in preclinical and clinical studies suggest that LDR-mediated immune modulation is a well-orchestrated phenomenon with clinical potential. We summarize recent developments in the understanding of LDR-mediated immune modulation, with an emphasis on its potential clinical applications. View Full-Text
Keywords: low-dose radiation; hormesis; immune stimulating; immune therapy; autoimmune disease; cancer therapy low-dose radiation; hormesis; immune stimulating; immune therapy; autoimmune disease; cancer therapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Cui, J.; Yang, G.; Pan, Z.; Zhao, Y.; Liang, X.; Li, W.; Cai, L. Hormetic Response to Low-Dose Radiation: Focus on the Immune System and Its Clinical Implications. Int. J. Mol. Sci. 2017, 18, 280.

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