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Int. J. Mol. Sci. 2017, 18(2), 257; doi:10.3390/ijms18020257

Plasma Triglyceride Levels May Be Modulated by Gene Expression of IQCJ, NXPH1, PHF17 and MYB in Humans

1
Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 Hochelaga Blvd, Quebec, QC G1V 0A6, Canada
2
CHU de Québec Research Center–Endocrinology and Nephrology, 2705 Laurier Blvd, Quebec, QC G1V 4G2, Canada
*
Author to whom correspondence should be addressed.
Academic Editors: Lynnette Ferguson and Virginia R. Parslow
Received: 27 October 2016 / Revised: 12 January 2017 / Accepted: 17 January 2017 / Published: 26 January 2017
(This article belongs to the Special Issue Gene-Diet Interactions in Chronic Diseases)
View Full-Text   |   Download PDF [239 KB, uploaded 26 January 2017]

Abstract

A genome-wide association study (GWAS) by our group identified loci associated with the plasma triglyceride (TG) response to ω-3 fatty acid (FA) supplementation in IQCJ, NXPH1, PHF17 and MYB. Our aim is to investigate potential mechanisms underlying the associations between single nucleotide polymorphisms (SNPs) in the four genes and TG levels following ω-3 FA supplementation. 208 subjects received 3 g/day of ω-3 FA (1.9–2.2 g of EPA and 1.1 g of docosahexaenoic acid (DHA)) for six weeks. Plasma TG were measured before and after the intervention. 67 SNPs were selected to increase the density of markers near GWAS hits. Genome-wide expression and methylation analyses were conducted on respectively 30 and 35 participants’ blood sample together with in silico analyses. Two SNPs of IQCJ showed different affinities to splice sites depending on alleles. Expression levels were influenced by genotype for one SNP in NXPH1 and one in MYB. Associations between 12 tagged SNPs of IQCJ, 26 of NXPH1, seven of PHF17 and four of MYB and gene-specific CpG site methylation levels were found. The response of plasma TG to ω-3 FA supplementation may be modulated by the effect of DNA methylation on expression levels of genes revealed by GWAS. View Full-Text
Keywords: gene-diet interactions; plasma lipid levels; ω-3 fatty acids; genome-wide association study; nutrigenetics; epigenetics gene-diet interactions; plasma lipid levels; ω-3 fatty acids; genome-wide association study; nutrigenetics; epigenetics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Vallée Marcotte, B.; Guénard, F.; Cormier, H.; Lemieux, S.; Couture, P.; Rudkowska, I.; Vohl, M.-C. Plasma Triglyceride Levels May Be Modulated by Gene Expression of IQCJ, NXPH1, PHF17 and MYB in Humans. Int. J. Mol. Sci. 2017, 18, 257.

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