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Int. J. Mol. Sci. 2017, 18(2), 236; doi:10.3390/ijms18020236

Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway

Department of Surgery, Trinity College Dublin, Dublin 8, Ireland
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Author to whom correspondence should be addressed.
Academic Editor: Li Yang
Received: 29 November 2016 / Revised: 3 January 2017 / Accepted: 13 January 2017 / Published: 24 January 2017
(This article belongs to the Special Issue Tumor Microenvironment and Metabolism)
View Full-Text   |   Download PDF [1576 KB, uploaded 24 January 2017]   |  

Abstract

5-lipoxygenase is an enzyme responsible for the synthesis of a range of bioactive lipids signalling molecules known collectively as eicosanoids. 5-lipoxygenase metabolites such as 5-hydroxyeicosatetraenoic acid (5-HETE) and a number of leukotrienes are mostly derived from arachidonic acid and have been shown to be lipid mediators of inflammation in different pathological states including cancer. Upregulated 5-lipoxygenase expression and metabolite production is found in a number of cancer types and has been shown to be associated with increased tumorigenesis. 5-lipoxygenase activity is present in a number of diverse cell types of the immune system and connective tissue. In this review, we discuss potential routes through which cancer cells may utilise the 5-lipoxygenase pathway to interact with the tumour microenvironment during the development and progression of a tumour. Furthermore, immune-derived 5-lipoxygenase signalling can drive both pro- and anti-tumour effects depending on the immune cell subtype and an overview of evidence for these opposing effects is presented. View Full-Text
Keywords: 5-lipoxygenase; leukotrienes; tumour microenvironment; angiogenesis; immune cells; adipose tissue 5-lipoxygenase; leukotrienes; tumour microenvironment; angiogenesis; immune cells; adipose tissue
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Moore, G.Y.; Pidgeon, G.P. Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway. Int. J. Mol. Sci. 2017, 18, 236.

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