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Int. J. Mol. Sci. 2017, 18(12), 2779; https://doi.org/10.3390/ijms18122779

Anomalous Behavior of Hyaluronan Crosslinking Due to the Presence of Excess Phospholipids in the Articular Cartilage System of Osteoarthritis

1
Institute of Mathematics and Physics, UTP University of Science and Technology, PL 85796 Bydgoszcz, Poland
2
Atomic and Optical Physics Division, Department of Atomic, Molecular and Optical Physics, Gdańsk University of Technology, PL 80233 Gdańsk, Poland
3
Faculty of Telecommunications, Computer Science and Technology, UTP University of Science and Technology, PL 85796 Bydgoszcz, Poland
4
Department of Research and Development, NuOrtho Surgical, Inc., Boston, MA 02723, USA
5
College of Mathematics, Natural Sciences and Technology, Delaware State University, Dover, DE 19901, USA
*
Author to whom correspondence should be addressed.
Received: 1 November 2017 / Revised: 29 November 2017 / Accepted: 8 December 2017 / Published: 20 December 2017
(This article belongs to the Section Molecular Biophysics)
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Abstract

Lubrication of articular cartilage is a complex multiscale phenomenon in synovial joint organ systems. In these systems, synovial fluid properties result from synergistic interactions between a variety of molecular constituent. Two molecular classes in particular are of importance in understanding lubrication mechanisms: hyaluronic acid and phospholipids. The purpose of this study is to evaluate interactions between hyaluronic acid and phospholipids at various functionality levels during normal and pathological synovial fluid conditions. Molecular dynamic simulations of hyaluronic acid and phospholipids complexes were performed with the concentration of hyaluronic acid set at a constant value for two organizational forms, extended (normal) and coiled (pathologic). The results demonstrated that phospholipids affect the crosslinking mechanisms of hyaluronic acid significantly and the influence is higher during pathological conditions. During normal conditions, hyaluronic acid and phospholipid interactions seem to have no competing mechanism to that of the interaction between hyaluronic acid to hyaluronic acid. On the other hand, the structures formed under pathologic conditions were highly affected by phospholipid concentration. View Full-Text
Keywords: hyaluronic acid; phospholipids; lubrication; articular cartilage; molecular dynamics simulations hyaluronic acid; phospholipids; lubrication; articular cartilage; molecular dynamics simulations
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Bełdowski, P.; Weber, P.; Andrysiak, T.; Augé II, W.K.; Ledziński, D.; De Leon, T.; Gadomski, A. Anomalous Behavior of Hyaluronan Crosslinking Due to the Presence of Excess Phospholipids in the Articular Cartilage System of Osteoarthritis. Int. J. Mol. Sci. 2017, 18, 2779.

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