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Int. J. Mol. Sci. 2017, 18(12), 2659; https://doi.org/10.3390/ijms18122659

LncRNA Structural Characteristics in Epigenetic Regulation

1
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China
2
Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China
*
Authors to whom correspondence should be addressed.
Received: 27 October 2017 / Revised: 24 November 2017 / Accepted: 26 November 2017 / Published: 8 December 2017
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Abstract

The rapid development of new generation sequencing technology has deepened the understanding of genomes and functional products. RNA-sequencing studies in mammals show that approximately 85% of the DNA sequences have RNA products, for which the length greater than 200 nucleotides (nt) is called long non-coding RNAs (lncRNA). LncRNAs now have been shown to play important epigenetic regulatory roles in key molecular processes, such as gene expression, genetic imprinting, histone modification, chromatin dynamics, and other activities by forming specific structures and interacting with all kinds of molecules. This paper mainly discusses the correlation between the structure and function of lncRNAs with the recent progress in epigenetic regulation, which is important to the understanding of the mechanism of lncRNAs in physiological and pathological processes. View Full-Text
Keywords: lncRNA structure; epigenetic regulation; RNA-protein binding motif; regulation protein recruit lncRNA structure; epigenetic regulation; RNA-protein binding motif; regulation protein recruit
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Wang, C.; Wang, L.; Ding, Y.; Lu, X.; Zhang, G.; Yang, J.; Zheng, H.; Wang, H.; Jiang, Y.; Xu, L. LncRNA Structural Characteristics in Epigenetic Regulation. Int. J. Mol. Sci. 2017, 18, 2659.

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