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Int. J. Mol. Sci. 2017, 18(12), 2633; https://doi.org/10.3390/ijms18122633

Similarity and Differences in Inflammation-Related Characteristics of the Peripheral Immune System of Patients with Parkinson’s and Alzheimer’s Diseases

Laboratory of Cell Interactions, Department of Immunology, Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia
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Received: 16 October 2017 / Revised: 21 November 2017 / Accepted: 1 December 2017 / Published: 6 December 2017
(This article belongs to the Special Issue Inflammaging and Oxidative Stress in Aging and Age-Related Disorders)
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Abstract

Parkinson’s disease (PD) and Alzheimer’s disease (AD) are the most common age-related neurodegenerative disorders. Both diseases are characterized by chronic inflammation in the brain—neuroinflammation. The first signs of PD and AD are most often manifested in old age, in which the immune system is usually characterized by chronic inflammation, so-called “inflammaging” In recent years, there is growing evidence that pathogenesis of these diseases is connected with both regional and peripheral immune processes. Currently, the association of clinical signs of PD and AD with different characteristics of patient immune status is actively being researched. In this mini-review we compare the association of PD and AD alterations of a number of immune system parameters connected with the process of inflammation. View Full-Text
Keywords: Parkinson’s disease; Alzheimer’s disease; inflammation; neuroinflammation; peripheral immune system; cytokines; oxidative stress Parkinson’s disease; Alzheimer’s disease; inflammation; neuroinflammation; peripheral immune system; cytokines; oxidative stress
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Boyko, A.A.; Troyanova, N.I.; Kovalenko, E.I.; Sapozhnikov, A.M. Similarity and Differences in Inflammation-Related Characteristics of the Peripheral Immune System of Patients with Parkinson’s and Alzheimer’s Diseases. Int. J. Mol. Sci. 2017, 18, 2633.

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