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Int. J. Mol. Sci. 2017, 18(12), 2627; doi:10.3390/ijms18122627

Immunotherapy for Prostate Cancer: Where We Are Headed

1
Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via P. Maroncelli 40, 47014 Meldola, Italy
2
Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via P. Maroncelli 40, 47014 Meldola, Italy
3
Medical Oncology Department, Campus Bio-Medico University, Via Alvaro del Portillo 200, 00128 Rome, Italy
4
Unit of Biostatistics and Clinical Trials, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via P. Maroncelli 40, 47014 Meldola, Italy
5
Radiotherapy Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via P. Maroncelli 40, 47014 Meldola, Italy
6
Radiology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via P. Maroncelli 40, 47014 Meldola, Italy
7
Urology Unit, Forlì Hospital, Romagna Local Health Service, 47100 Forlì, Italy
*
Author to whom correspondence should be addressed.
Received: 22 October 2017 / Revised: 27 November 2017 / Accepted: 2 December 2017 / Published: 5 December 2017
(This article belongs to the Special Issue Targeting Immune Checkpoints and Immunotherapy)
View Full-Text   |   Download PDF [471 KB, uploaded 6 December 2017]   |  

Abstract

Prostate cancer is one of the most common malignant neoplasms in men worldwide, and is the fifth cause of cancer-related death. In recent years, a new generation of therapies have been approved for the management of metastatic disease. Moreover, the development of new immunotherapeutic drugs has become a novel frontier for the treatment of several tumor types; to date, numerous studies have investigated their potential activity, including in prostate cancer. In this article, we discuss the role of emerging immunotherapeutic drugs in prostate cancer patients. View Full-Text
Keywords: prostate cancer; immunotherapy; vaccines; CTLA4; PD1; PD-L1; antibodies prostate cancer; immunotherapy; vaccines; CTLA4; PD1; PD-L1; antibodies
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Schepisi, G.; Farolfi, A.; Conteduca, V.; Martignano, F.; De Lisi, D.; Ravaglia, G.; Rossi, L.; Menna, C.; Bellia, S.R.; Barone, D.; Gunelli, R.; De Giorgi, U. Immunotherapy for Prostate Cancer: Where We Are Headed. Int. J. Mol. Sci. 2017, 18, 2627.

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