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Int. J. Mol. Sci. 2017, 18(12), 2516; doi:10.3390/ijms18122516

Aptamer Bioinformatics

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR China
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Received: 31 October 2017 / Revised: 17 November 2017 / Accepted: 20 November 2017 / Published: 24 November 2017
(This article belongs to the Special Issue Aptamers)
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Abstract

Aptamers are short nucleic acid sequences capable of specific, high-affinity molecular binding. They are isolated via SELEX (Systematic Evolution of Ligands by Exponential Enrichment), an evolutionary process that involves iterative rounds of selection and amplification before sequencing and aptamer characterization. As aptamers are genetic in nature, bioinformatic approaches have been used to improve both aptamers and their selection. This review will discuss the advancements made in several enclaves of aptamer bioinformatics, including simulation of aptamer selection, fragment-based aptamer design, patterning of libraries, identification of lead aptamers from high-throughput sequencing (HTS) data and in silico aptamer optimization. View Full-Text
Keywords: aptamer; simulation; in silico selection; molecular dynamics; fragment based design; HTS aptamer; simulation; in silico selection; molecular dynamics; fragment based design; HTS
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kinghorn, A.B.; Fraser, L.A.; Liang, S.; Shiu, S.C.-C.; Tanner, J.A. Aptamer Bioinformatics. Int. J. Mol. Sci. 2017, 18, 2516.

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