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Int. J. Mol. Sci. 2016, 17(9), 1508; doi:10.3390/ijms17091508

Virtual Screening Approaches towards the Discovery of Toll-Like Receptor Modulators

Department of Chemical & Physical Biology, Centro de Investigaciones Biológicas, CIB-CSIC, C/Ramiro de Maeztu, 9, 28040 Madrid, Spain
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Author to whom correspondence should be addressed.
Academic Editors: Humberto González-Díaz, Jesús Vicente de Julián Ortiz and Dr.-Habil. Mihai V. Putz
Received: 13 May 2016 / Revised: 1 July 2016 / Accepted: 22 August 2016 / Published: 9 September 2016
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Abstract

This review aims to summarize the latest efforts performed in the search for novel chemical entities such as Toll-like receptor (TLR) modulators by means of virtual screening techniques. This is an emergent research field with only very recent (and successful) contributions. Identification of drug-like molecules with potential therapeutic applications for the treatment of a variety of TLR-regulated diseases has attracted considerable interest due to the clinical potential. Additionally, the virtual screening databases and computational tools employed have been overviewed in a descriptive way, widening the scope for researchers interested in the field. View Full-Text
Keywords: Toll-like receptor; TLR modulators; virtual screening; drug discovery; computational approaches Toll-like receptor; TLR modulators; virtual screening; drug discovery; computational approaches
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MDPI and ACS Style

Pérez-Regidor, L.; Zarioh, M.; Ortega, L.; Martín-Santamaría, S. Virtual Screening Approaches towards the Discovery of Toll-Like Receptor Modulators. Int. J. Mol. Sci. 2016, 17, 1508.

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