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Int. J. Mol. Sci. 2016, 17(9), 1508; doi:10.3390/ijms17091508

Virtual Screening Approaches towards the Discovery of Toll-Like Receptor Modulators

Department of Chemical & Physical Biology, Centro de Investigaciones Biológicas, CIB-CSIC, C/Ramiro de Maeztu, 9, 28040 Madrid, Spain
Author to whom correspondence should be addressed.
Academic Editors: Humberto González-Díaz, Jesús Vicente de Julián Ortiz and Dr.-Habil. Mihai V. Putz
Received: 13 May 2016 / Revised: 1 July 2016 / Accepted: 22 August 2016 / Published: 9 September 2016
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This review aims to summarize the latest efforts performed in the search for novel chemical entities such as Toll-like receptor (TLR) modulators by means of virtual screening techniques. This is an emergent research field with only very recent (and successful) contributions. Identification of drug-like molecules with potential therapeutic applications for the treatment of a variety of TLR-regulated diseases has attracted considerable interest due to the clinical potential. Additionally, the virtual screening databases and computational tools employed have been overviewed in a descriptive way, widening the scope for researchers interested in the field. View Full-Text
Keywords: Toll-like receptor; TLR modulators; virtual screening; drug discovery; computational approaches Toll-like receptor; TLR modulators; virtual screening; drug discovery; computational approaches

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Pérez-Regidor, L.; Zarioh, M.; Ortega, L.; Martín-Santamaría, S. Virtual Screening Approaches towards the Discovery of Toll-Like Receptor Modulators. Int. J. Mol. Sci. 2016, 17, 1508.

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