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Int. J. Mol. Sci. 2016, 17(9), 1502; doi:10.3390/ijms17091502

Pharmacogenomics in Pediatric Oncology: Review of Gene—Drug Associations for Clinical Use

1
Cansearch Research Laboratory, Geneva University Medical School, Avenue de la Roseraie 64, 1205 Geneva, Switzerland
2
Charles-Bruneau Cancer Center, Centre hospitalier universitaire Sainte-Justine, 4515 Rue de Rouen, Montreal, QC H1V 1H1, Canada
3
Department of Pediatrics, University of Montreal, 2900 Boulevard Edouard-Montpetit, Montreal, QC H3T 1J4, Canada
4
Department of Pharmacology, Faculty of Medicine, University of Montreal, 2900 Boulevard Edouard-Montpetit, Montreal, QC H3T 1J4, Canada
5
Pediatric Department, Onco-Hematology Unit, Geneva University Hospital, Rue Willy-Donzé 6, 1205 Geneva, Switzerland
This paper was published on behalf of the Pediatric individualized treatment in oncology and hematology committee of the European Society of Pharmacogenomics and Personalised Therapy (ESPT).
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 21 July 2016 / Revised: 2 August 2016 / Accepted: 15 August 2016 / Published: 8 September 2016
(This article belongs to the Special Issue Precision Medicine—From Bench to Bedside)
View Full-Text   |   Download PDF [1271 KB, uploaded 8 September 2016]   |  

Abstract

During the 3rd congress of the European Society of Pharmacogenomics and Personalised Therapy (ESPT) in Budapest in 2015, a preliminary meeting was held aimed at establishing a pediatric individualized treatment in oncology and hematology committees. The main purpose was to facilitate the transfer and harmonization of pharmacogenetic testing from research into clinics, to bring together basic and translational research and to educate health professionals throughout Europe. The objective of this review was to provide the attendees of the meeting as well as the larger scientific community an insight into the compiled evidence regarding current pharmacogenomics knowledge in pediatric oncology. This preliminary evaluation will help steer the committee’s work and should give the reader an idea at which stage researchers and clinicians are, in terms of personalizing medicine for children with cancer. From the evidence presented here, future recommendations to achieve this goal will also be suggested. View Full-Text
Keywords: pediatrics; pharmacogenomics; PharmGKB; thiopurine; cisplatin; methotrexate; cyclophosphamide; irinotecan pediatrics; pharmacogenomics; PharmGKB; thiopurine; cisplatin; methotrexate; cyclophosphamide; irinotecan
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Mlakar, V.; Huezo-Diaz Curtis, P.; Satyanarayana Uppugunduri, C.R.; Krajinovic, M.; Ansari, M. Pharmacogenomics in Pediatric Oncology: Review of Gene—Drug Associations for Clinical Use. Int. J. Mol. Sci. 2016, 17, 1502.

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