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Int. J. Mol. Sci. 2016, 17(8), 1323; doi:10.3390/ijms17081323

The Role of Matrix Metalloproteinase Polymorphisms in Ischemic Stroke

1
Department of Neurology, University of Tennessee Health Science Center, Memphis, TN 38104, USA
2
Department of Nursing and Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38104, USA
3
Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38104, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Masatoshi Maki
Received: 23 June 2016 / Revised: 22 July 2016 / Accepted: 26 July 2016 / Published: 12 August 2016
(This article belongs to the Special Issue Metalloproteins)
View Full-Text   |   Download PDF [237 KB, uploaded 12 August 2016]

Abstract

Stroke remains the fifth leading cause of mortality in the United States with an annual rate of over 128,000 deaths per year. Differences in incidence, pathogenesis, and clinical outcome have long been noted when comparing ischemic stroke among different ethnicities. The observation that racial disparities exist in clinical outcomes after stroke has resulted in genetic studies focusing on specific polymorphisms. Some studies have focused on matrix metalloproteinases (MMPs). MMPs are a ubiquitous group of proteins with extensive roles that include extracellular matrix remodeling and blood-brain barrier disruption. MMPs play an important role in ischemic stroke pathophysiology and clinical outcome. This review will evaluate the evidence for associations between polymorphisms in MMP-1, 2, 3, 9, and 12 with ischemic stroke incidence, pathophysiology, and clinical outcome. The role of polymorphisms in MMP genes may influence the presentation of ischemic stroke and be influenced by racial and ethnic background. However, contradictory evidence for the role of MMP polymorphisms does exist in the literature, and further studies will be necessary to consolidate our understanding of these multi-faceted proteins. View Full-Text
Keywords: ischemic stroke; matrix metalloproteinase; polymorphism; incidence; epidemiology ischemic stroke; matrix metalloproteinase; polymorphism; incidence; epidemiology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chang, J.J.; Stanfill, A.; Pourmotabbed, T. The Role of Matrix Metalloproteinase Polymorphisms in Ischemic Stroke. Int. J. Mol. Sci. 2016, 17, 1323.

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