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Int. J. Mol. Sci. 2016, 17(8), 1322; doi:10.3390/ijms17081322

Telocytes and Their Extracellular Vesicles—Evidence and Hypotheses

1,2,†
,
3,†
,
4,* and 1,2,*
1
Division of Cellular and Molecular Biology and Histology, Department of Morphological Sciences, Carol Davila University of Medicine and Pharmacy, Bucharest 050474, Romania
2
Victor Babeş National Institute of Pathology, Bucharest 050096, Romania
3
Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China
4
Cardiac Regeneration and Ageing Lab, Experimental Center of Life Sciences, School of Life Science, Shanghai University, Shanghai 200444, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Gregor Drummen
Received: 29 June 2016 / Revised: 25 July 2016 / Accepted: 26 July 2016 / Published: 12 August 2016
(This article belongs to the Special Issue Focus on Extracellular Vesicles)
View Full-Text   |   Download PDF [5206 KB, uploaded 12 August 2016]   |  

Abstract

Entering the new millennium, nobody believed that there was the possibility of discovering a new cellular type. Nevertheless, telocytes (TCs) were described as a novel kind of interstitial cell. Ubiquitously distributed in the extracellular matrix of any tissue, TCs are regarded as cells with telopodes involved in intercellular communication by direct homo- and heterocellular junctions or by extracellular vesicle (EVs) release. Their discovery has aroused the interest of many research groups worldwide, and many researchers regard them as potentially regenerative cells. Given the experience of our laboratory, where these cells were first described, we review the evidence supporting the fact that TCs release EVs, and discuss alternative hypotheses about their future implications. View Full-Text
Keywords: telocytes; telopodes; extracellular vesicles; exosomes; ectosomes telocytes; telopodes; extracellular vesicles; exosomes; ectosomes
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Cretoiu, D.; Xu, J.; Xiao, J.; Cretoiu, S.M. Telocytes and Their Extracellular Vesicles—Evidence and Hypotheses. Int. J. Mol. Sci. 2016, 17, 1322.

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