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Int. J. Mol. Sci. 2016, 17(8), 1279; doi:10.3390/ijms17081279

Epigenetic Modifications of Major Depressive Disorder

Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de La Frontera, Temuco 4811230, Chile
Millennium Institute for Research in Depression and Personality (MIDAP), Universidad de La Frontera, Temuco 4811230, Chile
Author to whom correspondence should be addressed.
Academic Editor: Stephen A. Bustin
Received: 20 June 2016 / Revised: 24 July 2016 / Accepted: 29 July 2016 / Published: 5 August 2016
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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Major depressive disorder (MDD) is a chronic disease whose neurological basis and pathophysiology remain poorly understood. Initially, it was proposed that genetic variations were responsible for the development of this disease. Nevertheless, several studies within the last decade have provided evidence suggesting that environmental factors play an important role in MDD pathophysiology. Alterations in epigenetics mechanism, such as DNA methylation, histone modification and microRNA expression could favor MDD advance in response to stressful experiences and environmental factors. The aim of this review is to describe genetic alterations, and particularly altered epigenetic mechanisms, that could be determinants for MDD progress, and how these alterations may arise as useful screening, diagnosis and treatment monitoring biomarkers of depressive disorders. View Full-Text
Keywords: major depressive disorder; depression; epigenetic modifications; methylation; histone modification; miRNAs; biomarkers major depressive disorder; depression; epigenetic modifications; methylation; histone modification; miRNAs; biomarkers

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Saavedra, K.; Molina-Márquez, A.M.; Saavedra, N.; Zambrano, T.; Salazar, L.A. Epigenetic Modifications of Major Depressive Disorder. Int. J. Mol. Sci. 2016, 17, 1279.

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