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Int. J. Mol. Sci. 2016, 17(7), 1171; doi:10.3390/ijms17071171

Developments in Methods for Measuring the Intestinal Absorption of Nanoparticle-Bound Drugs

1
Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China
2
Department of Pharmaceutics, School of Pharmacy, Zhengzhou University, 100 Science Avenue, Zhengzhou 450001, China
3
School of Pharmacy, Queen’s University Belfast, Belfast BT7 1NN, UK
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Már Másson
Received: 27 May 2016 / Revised: 12 July 2016 / Accepted: 13 July 2016 / Published: 21 July 2016
(This article belongs to the Section Biomaterial Sciences)
View Full-Text   |   Download PDF [2205 KB, uploaded 21 July 2016]   |  

Abstract

With the rapid development of nanotechnology, novel drug delivery systems comprising orally administered nanoparticles (NPs) have been paid increasing attention in recent years. The bioavailability of orally administered drugs has significant influence on drug efficacy and therapeutic dosage, and it is therefore imperative that the intestinal absorption of oral NPs be investigated. This review examines the various literature on the oral absorption of polymeric NPs, and provides an overview of the intestinal absorption models that have been developed for the study of oral nanoparticles. Three major categories of models including a total of eight measurement methods are described in detail (in vitro: dialysis bag, rat gut sac, Ussing chamber, cell culture model; in situ: intestinal perfusion, intestinal loops, intestinal vascular cannulation; in vivo: the blood/urine drug concentration method), and the advantages and disadvantages of each method are contrasted and elucidated. In general, in vitro and in situ methods are relatively convenient but lack accuracy, while the in vivo method is troublesome but can provide a true reflection of drug absorption in vivo. This review summarizes the development of intestinal absorption experiments in recent years and provides a reference for the systematic study of the intestinal absorption of nanoparticle-bound drugs. View Full-Text
Keywords: drug delivery; polymeric nanoparticles (NPs); intestinal absorption; in vitro; in situ; in vivo drug delivery; polymeric nanoparticles (NPs); intestinal absorption; in vitro; in situ; in vivo
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MDPI and ACS Style

Liu, W.; Pan, H.; Zhang, C.; Zhao, L.; Zhao, R.; Zhu, Y.; Pan, W. Developments in Methods for Measuring the Intestinal Absorption of Nanoparticle-Bound Drugs. Int. J. Mol. Sci. 2016, 17, 1171.

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