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Int. J. Mol. Sci. 2016, 17(6), 889; doi:10.3390/ijms17060889

Could Vitamin D Analogues Be Used to Target Leukemia Stem Cells?

1
Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca, Campus M. de Unamuno s/n, Salamanca 37007, Spain
2
Cancer Research Area, Institute of Biomedical Research of Salamanca (IBSAL), Salamanca 37007, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Roman Perez-Fernandez
Received: 25 April 2016 / Revised: 23 May 2016 / Accepted: 31 May 2016 / Published: 6 June 2016
View Full-Text   |   Download PDF [1302 KB, uploaded 6 June 2016]   |  

Abstract

Leukemic stem cells (LSCs) are defined as cells that possess the ability to self-renew and give rise to the differentiated cancer cells that comprise the tumor. These LSCs seem to show chemo-resistance and radio-resistance leading to the failure of conventional cancer therapies. Current therapies are directed at the fast growing tumor mass leaving the LSC fraction untouched. Eliminating LSCs, the root of cancer origin and recurrence, is considered to be a hopeful approach to improve survival or even to cure cancer patients. In order to achieve this, the characterization of LSCs is a prerequisite in order to develop LSC-based therapies to eliminate them. Here we review if vitamin D analogues may allow an avenue to target the LSCs. View Full-Text
Keywords: cancer; stem cells; vitamin D; cancer stem cells; mouse models; leukemia therapy cancer; stem cells; vitamin D; cancer stem cells; mouse models; leukemia therapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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García-Ramírez, I.; Martín-Lorenzo, A.; González-Herrero, I.; Rodriguez-Hernández, G.; Vicente-Dueñas, C.; Sánchez-García, I. Could Vitamin D Analogues Be Used to Target Leukemia Stem Cells? Int. J. Mol. Sci. 2016, 17, 889.

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