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Int. J. Mol. Sci. 2016, 17(6), 877; doi:10.3390/ijms17060877

Involvement and Clinical Aspects of MicroRNA in Osteosarcoma

1
Department of Experimental Pathology, CHUV and University of Lausanne, 1011 Lausanne, Switzerland
2
Laboratory for Orthopaedic Research, Department of Orthopaedics, Balgrist University Hospital, University of Zurich, 8008 Zurich, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: William Cho
Received: 25 April 2016 / Revised: 24 May 2016 / Accepted: 27 May 2016 / Published: 3 June 2016
(This article belongs to the Special Issue MicroRNA in Various Disease States as Biomarkers)
View Full-Text   |   Download PDF [194 KB, uploaded 3 June 2016]

Abstract

Osteosarcoma (OS) is the most common primary bone cancer in children and adolescents, but its pathogenesis has been difficult to establish because of its well-known heterogeneous nature. OS has been associated with genetic and cytogenetic abnormalities, which include function-impairing mutations in tumor suppressors and the activation of oncogenes. OS tumorigenesis has been linked to alterations of several genes characterized by a high level of genetic instability and recurrent DNA amplifications and deletions. MicroRNAs (miRNAs), 18–25-nucleotide noncoding RNAs, are critical for various biological processes like differentiation, cell growth and cell death. Dysregulation of miRNA expression leads to phenotypic and genotypic changes in cells, which leads to cancer. Studies on miRNAs have initiated a significant effect in both diagnosis and treatment of cancer. This review focuses on the current knowledge of clinical applications of miRNAs for the better diagnosis and management of OS. View Full-Text
Keywords: osteosarcoma; metastasis; microRNA; biomarker; cancer osteosarcoma; metastasis; microRNA; biomarker; cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ram Kumar, R.M.; Boro, A.; Fuchs, B. Involvement and Clinical Aspects of MicroRNA in Osteosarcoma. Int. J. Mol. Sci. 2016, 17, 877.

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