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Int. J. Mol. Sci. 2016, 17(6), 875; doi:10.3390/ijms17060875

Neonatal Heart-Enriched miR-708 Promotes Differentiation of Cardiac Progenitor Cells in Rats

1
Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine, Translational Medical Center for Stem Cell Therapy, East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai 200120, China
2
Sino-French Cooperative Central Laboratory, Shanghai Gongli Hospital, Second Military Medical University, Shanghai 200135, China
3
Department of Anesthesia, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200120, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Y-h. Taguchi
Received: 14 April 2016 / Revised: 19 May 2016 / Accepted: 27 May 2016 / Published: 7 June 2016
(This article belongs to the Special Issue MicroRNA Regulation)
View Full-Text   |   Download PDF [2731 KB, uploaded 7 June 2016]   |  

Abstract

Cardiovascular disease is becoming the leading cause of death throughout the world. However, adult hearts have limited potential for regeneration after pathological injury, partly due to the quiescent status of stem/progenitor cells. Reactivation of cardiac stem/progenitor cells to create more myocyte progeny is one of the key steps in the regeneration of a damaged heart. In this study, miR-708 was identified to be enriched in the neonatal cardiomyocytes of rats, but this has not yet been proven in adult humans. A lower level of miR-708 in c-kit(+) stem/progenitor cells was detected compared to non-progenitors. Overexpression of miR-708 induced cardiomyocyte differentiation of cardiac stem/progenitor cells. This finding strengthened the potential of applying miRNAs in the regeneration of injured hearts, and this indicates that miR-708 could be a novel candidate for treatment of heart diseases. View Full-Text
Keywords: miR-708; cardiac stem/progenitor cells; cardiomyocytes; heart regeneration miR-708; cardiac stem/progenitor cells; cardiomyocytes; heart regeneration
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Deng, S.; Zhao, Q.; Zhou, X.; Zhang, L.; Bao, L.; Zhen, L.; Zhang, Y.; Fan, H.; Liu, Z.; Yu, Z. Neonatal Heart-Enriched miR-708 Promotes Differentiation of Cardiac Progenitor Cells in Rats. Int. J. Mol. Sci. 2016, 17, 875.

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