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Int. J. Mol. Sci. 2016, 17(5), 776; doi:10.3390/ijms17050776

Integrated Analysis of Expression Profile Based on Differentially Expressed Genes in Middle Cerebral Artery Occlusion Animal Models

1
Department of Anesthesiology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
2
Sun Yat-sen University School of Medicine, Sun Yat-sen University, Guangzhou 510080, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Joseph V. Moxon
Received: 5 April 2016 / Revised: 10 May 2016 / Accepted: 16 May 2016 / Published: 20 May 2016
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
View Full-Text   |   Download PDF [1096 KB, uploaded 20 May 2016]   |  

Abstract

Stroke is one of the most common causes of death, only second to heart disease. Molecular investigations about stroke are in acute shortage nowadays. This study is intended to explore a gene expression profile after brain ischemia reperfusion. Meta-analysis, differential expression analysis, and integrated analysis were employed on an eight microarray series. We explored the functions and pathways of target genes in gene ontology (GO) enrichment analysis and constructed a protein-protein interaction network. Meta-analysis identified 360 differentially expressed genes (DEGs) for Mus musculus and 255 for Rattus norvegicus. Differential expression analysis identified 44 DEGs for Mus musculus and 21 for Rattus norvegicus. Timp1 and Lcn2 were overexpressed in both species. The cytokine-cytokine receptor interaction and chemokine signaling pathway were highly enriched for the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. We have exhibited a global view of the potential molecular differences between middle cerebral artery occlusion (MCAO) animal model and sham for Mus musculus or Rattus norvegicus, including the biological process and enriched pathways in DEGs. This research helps contribute to a clearer understanding of the inflammation process and accurate identification of ischemic infarction stages, which might be transformed into a therapeutic approach. View Full-Text
Keywords: gene expression profile; stroke; middle cerebral artery occlusion; cytokines gene expression profile; stroke; middle cerebral artery occlusion; cytokines
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhou, H.; Qiu, Z.; Gao, S.; Chen, Q.; Li, S.; Tan, W.; Liu, X.; Wang, Z. Integrated Analysis of Expression Profile Based on Differentially Expressed Genes in Middle Cerebral Artery Occlusion Animal Models. Int. J. Mol. Sci. 2016, 17, 776.

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